2021
Blood virosphere in febrile Tanzanian children
Cordey S, Laubscher F, Hartley M, Junier T, Keitel K, Docquier M, Guex N, Iseli C, Vieille G, Le Mercier P, Gleizes A, Samaka J, Mlaganile T, Kagoro F, Masimba J, Said Z, Temba H, Elbanna G, Tapparel C, Zanella M, Xenarios I, Fellay J, D’Acremont V, Kaiser L. Blood virosphere in febrile Tanzanian children. Emerging Microbes & Infections 2021, 10: 982-993. PMID: 33929935, PMCID: PMC8171259, DOI: 10.1080/22221751.2021.1925161.Peer-Reviewed Original ResearchConceptsInfection/diseaseBlood viromeMetagenomic next-generation sequencingAcute febrile illnessLow-resource clinical settingsAvailable diagnostic toolsFebrile childrenFebrile illnessPediatric populationOutpatient departmentRoutine screeningTanzanian childrenViral infectionPotential viral originViral variantsClinical settingOne-yearDetected virusNext-generation sequencingDar es SalaamDiagnostic toolCausal virusVirusViral originDisease
2017
Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease
Hartley M, Young A, Tran A, Okoni-Williams H, Suma M, Mancuso B, Al-Dikhari A, Faouzi M. Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease. PLOS Neglected Tropical Diseases 2017, 11: e0005356. PMID: 28231242, PMCID: PMC5322888, DOI: 10.1371/journal.pntd.0005356.Peer-Reviewed Original ResearchConceptsEbola virus diseaseEbola treatment centersEVD infectionTriage scoreDifferential diagnosisRetrospective cohort studyNon-specific symptomsImportant differential diagnosisPrevention/control measuresVirus diseaseCurrent triage protocolResource-poor settingsClinical characteristicsCohort studyEVD patientsUnivariate analysisNosocomial infectionsHigher oddsTriage toolPredictive scoreTreatment centersTriage protocolMultivariate analysisPatientsDifferential diagnosticsPredicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease
Hartley M, Young A, Tran A, Okoni-Williams H, Suma M, Mancuso B, Al-Dikhari A, Faouzi M. Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease. PLOS Neglected Tropical Diseases 2017, 11: e0005265. PMID: 28151955, PMCID: PMC5289426, DOI: 10.1371/journal.pntd.0005265.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildEbolavirusFemaleHemorrhagic Fever, EbolaHumansMalePrognosisRetrospective StudiesSierra LeoneYoung AdultConceptsEbola virus diseaseViral loadPrognostic toolEbola viral loadMultivariate prognostic scoreRetrospective cohort studyEbola treatment centersAccurate prognostic toolVirus diseaseEVD mortalityClinical characteristicsCohort studyPrognostic scoreAsymptomatic infectionClinical severityIntensive treatmentPrognostic potentialUnadjusted predictorsDisease scoreMortality rateTreatment centersEVD diagnosisMortality risk reductionDeadly infectionEarly reporting