2022
Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study
Laubscher F, Hartley M, Kaiser L, Cordey S. Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study. Viruses 2022, 14: 1612. PMID: 35893678, PMCID: PMC9330782, DOI: 10.3390/v14081612.Peer-Reviewed Original ResearchConceptsTorque teno virusBlood samplesPediatric outpatientsMetagenomic next-generation sequencingFebrile pediatric outpatientsDescriptive cohort studyHuman blood viromeCohort studyIndividual blood samplesPatient ageTanzanian childrenBlood viromeSignificant associationMixed genotypesMonths/yearsTTV speciesNext-generation sequencingPositive samplesAgeOutpatientsFirst months/yearsMedianSubjectsVirusGenotypes
2021
Blood virosphere in febrile Tanzanian children
Cordey S, Laubscher F, Hartley M, Junier T, Keitel K, Docquier M, Guex N, Iseli C, Vieille G, Le Mercier P, Gleizes A, Samaka J, Mlaganile T, Kagoro F, Masimba J, Said Z, Temba H, Elbanna G, Tapparel C, Zanella M, Xenarios I, Fellay J, D’Acremont V, Kaiser L. Blood virosphere in febrile Tanzanian children. Emerging Microbes & Infections 2021, 10: 982-993. PMID: 33929935, PMCID: PMC8171259, DOI: 10.1080/22221751.2021.1925161.Peer-Reviewed Original ResearchConceptsInfection/diseaseBlood viromeMetagenomic next-generation sequencingAcute febrile illnessLow-resource clinical settingsAvailable diagnostic toolsFebrile childrenFebrile illnessPediatric populationOutpatient departmentRoutine screeningTanzanian childrenViral infectionPotential viral originViral variantsClinical settingOne-yearDetected virusNext-generation sequencingDar es SalaamDiagnostic toolCausal virusVirusViral originDisease
2012
Backseat drivers: the hidden influence of microbial viruses on disease
Hartley M, Ronet C, Fasel N. Backseat drivers: the hidden influence of microbial viruses on disease. Current Opinion In Microbiology 2012, 15: 538-545. PMID: 22694933, DOI: 10.1016/j.mib.2012.05.011.Peer-Reviewed Original ResearchConceptsImportant clinical considerationsMicrobial virusesLeishmania virusDisease processClinical considerationsDiagnostic biomarkersTherapeutic interventionsViral replicationMolecular targetsVirusDiseaseViral hostHuman pathogensHuman diseasesFitness factorsPathogensPathogenesisPrevalenceIncidenceBiomarkers