2019
Machine-learning Prognostic Models from the 2014–16 Ebola Outbreak: Data-harmonization Challenges, Validation Strategies, and mHealth Applications
Colubri A, Hartley M, Siakor M, Wolfman V, Felix A, Sesay T, Shaffer J, Garry R, Grant D, Levine A, Sabeti P. Machine-learning Prognostic Models from the 2014–16 Ebola Outbreak: Data-harmonization Challenges, Validation Strategies, and mHealth Applications. EClinicalMedicine 2019, 11: 54-64. PMID: 31312805, PMCID: PMC6610774, DOI: 10.1016/j.eclinm.2019.06.003.Peer-Reviewed Original ResearchEbola virus diseasePrognostic modelEvidence-based care guidelinesMHealth toolsInformed accessSigns/symptomsEvidence-based guidelinesEbola treatment unitsMultivariate logistic regressionComprehensive clinical guidelinesInternational Medical CorpsViral loadCare guidelinesSurvival outcomesUS National InstitutesClinical guidelinesEVD epidemicEbola careClinical expertiseExperienced cliniciansSimilar AUCLogistic regressionMelinda Gates FoundationCost of specificityWellness assessmentDetection of dicistroviruses RNA in blood of febrile Tanzanian children
Cordey S, Laubscher F, Hartley M, Junier T, Pérez-Rodriguez F, Keitel K, Vieille G, Samaka J, Mlaganile T, Kagoro F, Boillat-Blanco N, Mbarack Z, Docquier M, Brito F, Eibach D, May J, Sothmann P, Aldrich C, Lusingu J, Tapparel C, D’Acremont V, Kaiser L. Detection of dicistroviruses RNA in blood of febrile Tanzanian children. Emerging Microbes & Infections 2019, 8: 613-623. PMID: 30999808, PMCID: PMC6493270, DOI: 10.1080/22221751.2019.1603791.Peer-Reviewed Original ResearchConceptsTanzanian childrenViral RNA copies/Paediatric outpatient consultationsRNA copies/Higher positivity rateReal-time RT-PCRQuantitative real-time RT-PCRTanzanian adultsFebrile episodesViral loadOutpatient consultationsPositivity rateCopies/Causative pathogenNew agentsRT-PCRPlasma samplesFull-length genomeSusceptible populationChildrenViral originFurther investigationBloodSerumCapsid region
2017
Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease
Hartley M, Young A, Tran A, Okoni-Williams H, Suma M, Mancuso B, Al-Dikhari A, Faouzi M. Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease. PLOS Neglected Tropical Diseases 2017, 11: e0005265. PMID: 28151955, PMCID: PMC5289426, DOI: 10.1371/journal.pntd.0005265.Peer-Reviewed Original ResearchConceptsEbola virus diseaseViral loadPrognostic toolEbola viral loadMultivariate prognostic scoreRetrospective cohort studyEbola treatment centersAccurate prognostic toolVirus diseaseEVD mortalityClinical characteristicsCohort studyPrognostic scoreAsymptomatic infectionClinical severityIntensive treatmentPrognostic potentialUnadjusted predictorsDisease scoreMortality rateTreatment centersEVD diagnosisMortality risk reductionDeadly infectionEarly reporting