2023
DeepBreath—automated detection of respiratory pathology from lung auscultation in 572 pediatric outpatients across 5 countries
Heitmann J, Glangetas A, Doenz J, Dervaux J, Shama D, Garcia D, Benissa M, Cantais A, Perez A, Müller D, Chavdarova T, Ruchonnet-Metrailler I, Siebert J, Lacroix L, Jaggi M, Gervaix A, Hartley M. DeepBreath—automated detection of respiratory pathology from lung auscultation in 572 pediatric outpatients across 5 countries. Npj Digital Medicine 2023, 6: 104. PMID: 37268730, PMCID: PMC10238513, DOI: 10.1038/s41746-023-00838-3.Peer-Reviewed Original ResearchAcute respiratory illnessPediatric outpatientsRespiratory illnessRespiratory pathologyLung auscultationReceiver operator characteristicHealthy controlsRespiratory rateThoracic sitesRespiratory cycleBronchiolitisPneumoniaOutpatientsPatientsPathological breathingIllnessPathologyAuscultationDisordersSignificant improvementObjective estimatesBreathingAUROCePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and middle-income countries
Tan R, Cobuccio L, Beynon F, Levine G, Vaezipour N, Luwanda L, Mangu C, Vonlanthen A, De Santis O, Salim N, Manji K, Naburi H, Chirande L, Matata L, Bulongeleje M, Moshiro R, Miheso A, Arimi P, Ndiaye O, Faye M, Thiongane A, Awasthi S, Sharma K, Kumar G, Van De Maat J, Kulinkina A, Rwandarwacu V, Dusengumuremyi T, Nkuranga J, Rusingiza E, Tuyisenge L, Hartley M, Faivre V, Thabard J, Keitel K, D’Acremont V. ePOCT+ and the medAL-suite: Development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low- and middle-income countries. PLOS Digital Health 2023, 2: e0000170. PMID: 36812607, PMCID: PMC9931356, DOI: 10.1371/journal.pdig.0000170.Peer-Reviewed Original ResearchClinical decision support algorithmsDecision support algorithmQuality of careMiddle-income settingsMiddle-income countriesReliability of clinical signsCountry of implementationMobile healthSupport algorithmImprove uptakeClinical contentPediatric outpatientsHealth authoritiesChildhood mortalityClinical expertsIntegrated development processProgramming skillsPerformance of predictorsAntibiotic prescriptionsClinical algorithmCliniciansCareClinical validation studiesEnd-usersAlgorithm suite
2022
Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study
Laubscher F, Hartley M, Kaiser L, Cordey S. Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study. Viruses 2022, 14: 1612. PMID: 35893678, PMCID: PMC9330782, DOI: 10.3390/v14081612.Peer-Reviewed Original ResearchConceptsTorque teno virusBlood samplesPediatric outpatientsMetagenomic next-generation sequencingFebrile pediatric outpatientsDescriptive cohort studyHuman blood viromeCohort studyIndividual blood samplesPatient ageTanzanian childrenBlood viromeSignificant associationMixed genotypesMonths/yearsTTV speciesNext-generation sequencingPositive samplesAgeOutpatientsFirst months/yearsMedianSubjectsVirusGenotypes
2020
Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study
Hartley M, Hofmann N, Keitel K, Kagoro F, Moniz C, Mlaganile T, Samaka J, Masimba J, Said Z, Temba H, Gonzalez I, Felger I, Genton B, D’Acremont V. Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study. PLOS Medicine 2020, 17: e1003318. PMID: 32956354, PMCID: PMC7505590, DOI: 10.1371/journal.pmed.1003318.Peer-Reviewed Original ResearchConceptsFebrile childrenLD patientsSecondary hospitalizationCohort studyLD infectionLow-density Plasmodium infectionsMalaria rapid diagnostic testsFebrile pediatric outpatientsPlasmodium falciparum parasitemiaPrimary care levelClinical decision support algorithmPrimary care facilitiesRapid diagnostic testsHigh-density infectionsViral originPediatric outpatientsUndifferentiated feverClinical featuresClinical presentationHD patientsSevere malnutritionClinical benefitIncidental findingPlasmodium infectionPolymerase chain reaction