2018
<i>Leishmania guyanensis</i> parasites block the activation of the inflammasome by inhibiting maturation of IL-1β
Hartley M, Eren R, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye L, Beverley S, Drexler S, Fasel N. Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β. Microbial Cell 2018, 5: 137. PMID: 29487860, PMCID: PMC5826701, DOI: 10.15698/mic2018.03.619.Peer-Reviewed Original ResearchRIG-like receptorsInflammasome pathwayInnate pattern recognition receptorsPotent innate immunogenPattern recognition receptorsCytoplasmic dsRNA sensorsLesional inflammationTLR3 pathwaySymptomatic outcomeIL-1βInflammatory pathologyInflammatory responseInflammasome activationCutaneous leishmaniasisRecognition receptorsParasite burdenReceptor 3DsRNA sensorsVirus 1InfectionPathologyViral dsRNA genomeInflammasomeA20 proteinLRV1
2016
Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence
Eren R, Reverte M, Rossi M, Hartley M, Castiglioni P, Prevel F, Martin R, Desponds C, Lye L, Drexler S, Reith W, Beverley S, Ronet C, Fasel N. Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence. Cell Host & Microbe 2016, 20: 318-328. PMID: 27593513, PMCID: PMC5493041, DOI: 10.1016/j.chom.2016.08.001.Peer-Reviewed Original ResearchConceptsLeishmania RNA virus 1Innate immune responseParasite persistenceImmune responseMiR-155Anti-viral innate immune responsesMacrophage survivalMiR-155-deficient miceTLR-3 activationMiR-155 expressionMammalian host responseMammalian innate immune responseLesional macrophagesParasitic infectionsHost responseDisease severityParasite burdenLeishmania guyanensisPharmacological inhibitionVirus 1Akt phosphorylationAkt activationReduced levelsSurvivalMice