2014
The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis
Hartley M, Drexler S, Ronet C, Beverley S, Fasel N. The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis. Trends In Parasitology 2014, 30: 412-422. PMID: 24954794, PMCID: PMC4287268, DOI: 10.1016/j.pt.2014.05.006.Peer-Reviewed Original ResearchConceptsInnate immune systemImmune systemSelf-healing cutaneous lesionsPattern recognition receptorsFacial mucosaMetastatic leishmaniasisMetastatic diseasePapular rashCutaneous lesionsSuch diverse pathologiesCutaneous systemHost immunocompetenceGranulomatous nodulesParasitic infectionsRecognition receptorsPotential associationCutaneous leishmaniasesDiverse pathologiesMillions of peoplePathologyMultiple secondary sitesSecondary sitesRashUlcerationMetastasis
2012
Leishmania RNA virus: when the host pays the toll
Hartley M, Ronet C, Zangger H, Beverley S, Fasel N. Leishmania RNA virus: when the host pays the toll. Frontiers In Cellular And Infection Microbiology 2012, 2: 99. PMID: 22919688, PMCID: PMC3417650, DOI: 10.3389/fcimb.2012.00099.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Mucocutaneous leishmaniasisHyper-inflammatory immune responseLeishmania parasitesPotent innate immunogenExperimental animal modelsType 1 interferonLeishmania RNA virusAnti-leishmanial drugsMetastatic leishmaniasisDestructive inflammationMetastatic complicationsMetastatic diseaseInflammatory cascadeInflammatory stateRNA virusesSecondary lesionsImmune responseAnimal modelsClinical isolatesDisease severityReceptor 3Leishmania guyanensisMetastatic factorsClinical interventions