2016
Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A
Hartley M, Bourreau E, Rossi M, Castiglioni P, Eren R, Prevel F, Couppié P, Hickerson S, Launois P, Beverley S, Ronet C, Fasel N. Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A. PLOS Pathogens 2016, 12: e1005852. PMID: 27658195, PMCID: PMC5033371, DOI: 10.1371/journal.ppat.1005852.Peer-Reviewed Original ResearchIL-17AMurine modelMetastatic leishmaniasisDisease chronicityHuman patientsInflammatory cytokines IL-17AIL-17A inhibitionPotent innate immunogenPresence of LRV1Cytokines IL-17AAbsence of IFNMetastatic complicationsImmunologic mechanismsStandard therapyCytokines IFNPrognostic valueOpen ulcerationDisease outcomeCutaneous leishmaniasisSecondary sitesSignificant associationLeishmania parasitesTherapeutic promiseLeishmaniasisLRV1Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus
Parmentier L, Cusini A, Müller N, Zangger H, Hartley M, Desponds C, Castiglioni P, Dubach P, Ronet C, Beverley S, Fasel N. Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus. American Journal Of Tropical Medicine And Hygiene 2016, 94: 840-843. PMID: 26834198, PMCID: PMC4824227, DOI: 10.4269/ajtmh.15-0803.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLeishmania infectionCutaneous leishmaniasisPresence of LRV1Primary skin lesionsDrug treatment failureAggressive pathogenesisAntiretroviral therapyHIV patientsSpecies of LeishmaniaMurine leishmaniasisTreatment failureImmunodeficiency virusNasal lesionsRisk factorsEmergence of leishmaniasisSkin lesionsCutaneous afflictionsFurther exacerbationDisease severityLeishmania parasitesLeishmaniasisLeishmania braziliensisLRV1Patients
2013
The therapeutic potential of immune cross‐talk in leishmaniasis
Hartley M, Kohl K, Ronet C, Fasel N. The therapeutic potential of immune cross‐talk in leishmaniasis. Clinical Microbiology And Infection 2013, 19: 119-130. PMID: 23398405, DOI: 10.1111/1469-0691.12095.Peer-Reviewed Original ResearchConceptsMetastatic leishmaniasisCutaneous leishmaniasisLeishmania parasitesSelf-healing lesionsProtozoan parasitic diseaseEffective antileishmanial drugsSpecies of LeishmaniaDestructive lesionsImmune homeostasisCurrent treatmentTherapeutic strategiesImmune pathwaysNew drug targetsTherapeutic potentialParasitic diseasesAntileishmanial drugsLeishmaniasisLesionsPrevalent formDiseaseDrug targetsRNA virusesTreatmentVariable effectsParasitesDetection of Leishmania RNA Virus in Leishmania Parasites
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Detection of Leishmania RNA Virus in Leishmania Parasites. PLOS Neglected Tropical Diseases 2013, 7: e2006. PMID: 23326619, PMCID: PMC3542153, DOI: 10.1371/journal.pntd.0002006.Peer-Reviewed Original ResearchConceptsLeishmania RNA virusCutaneous leishmaniasisSkin lesionsPresence of LRVHyper-inflammatory immune responsePrimary skin lesionsUlcerated skin lesionsOverall exacerbationsSignificant morbidityInfected miceLesion biopsyRNA virusesSecondary lesionsImmune responseHigh riskNew World Leishmania speciesAggressive phenotypeLeishmania strainsLeishmania parasitesPatient samplesViral detectionMonoclonal antibodiesNasopharyngeal tissuesParasite strainsMetastatic phenotype
2012
Leishmania RNA virus: when the host pays the toll
Hartley M, Ronet C, Zangger H, Beverley S, Fasel N. Leishmania RNA virus: when the host pays the toll. Frontiers In Cellular And Infection Microbiology 2012, 2: 99. PMID: 22919688, PMCID: PMC3417650, DOI: 10.3389/fcimb.2012.00099.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Mucocutaneous leishmaniasisHyper-inflammatory immune responseLeishmania parasitesPotent innate immunogenExperimental animal modelsType 1 interferonLeishmania RNA virusAnti-leishmanial drugsMetastatic leishmaniasisDestructive inflammationMetastatic complicationsMetastatic diseaseInflammatory cascadeInflammatory stateRNA virusesSecondary lesionsImmune responseAnimal modelsClinical isolatesDisease severityReceptor 3Leishmania guyanensisMetastatic factorsClinical interventions