<i>Leishmania guyanensis</i> parasites block the activation of the inflammasome by inhibiting maturation of IL-1β
Hartley M, Eren R, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye L, Beverley S, Drexler S, Fasel N. Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β. Microbial Cell 2018, 5: 137. PMID: 29487860, PMCID: PMC5826701, DOI: 10.15698/mic2018.03.619.Peer-Reviewed Original ResearchRIG-like receptorsInflammasome pathwayInnate pattern recognition receptorsPotent innate immunogenPattern recognition receptorsCytoplasmic dsRNA sensorsLesional inflammationTLR3 pathwaySymptomatic outcomeIL-1βInflammatory pathologyInflammatory responseInflammasome activationCutaneous leishmaniasisRecognition receptorsParasite burdenReceptor 3DsRNA sensorsVirus 1InfectionPathologyViral dsRNA genomeInflammasomeA20 proteinLRV1