2022
Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study
Laubscher F, Hartley M, Kaiser L, Cordey S. Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study. Viruses 2022, 14: 1612. PMID: 35893678, PMCID: PMC9330782, DOI: 10.3390/v14081612.Peer-Reviewed Original ResearchConceptsTorque teno virusBlood samplesPediatric outpatientsMetagenomic next-generation sequencingFebrile pediatric outpatientsDescriptive cohort studyHuman blood viromeCohort studyIndividual blood samplesPatient ageTanzanian childrenBlood viromeSignificant associationMixed genotypesMonths/yearsTTV speciesNext-generation sequencingPositive samplesAgeOutpatientsFirst months/yearsMedianSubjectsVirusGenotypes
2020
Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study
Hartley M, Hofmann N, Keitel K, Kagoro F, Moniz C, Mlaganile T, Samaka J, Masimba J, Said Z, Temba H, Gonzalez I, Felger I, Genton B, D’Acremont V. Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study. PLOS Medicine 2020, 17: e1003318. PMID: 32956354, PMCID: PMC7505590, DOI: 10.1371/journal.pmed.1003318.Peer-Reviewed Original ResearchConceptsFebrile childrenLD patientsSecondary hospitalizationCohort studyLD infectionLow-density Plasmodium infectionsMalaria rapid diagnostic testsFebrile pediatric outpatientsPlasmodium falciparum parasitemiaPrimary care levelClinical decision support algorithmPrimary care facilitiesRapid diagnostic testsHigh-density infectionsViral originPediatric outpatientsUndifferentiated feverClinical featuresClinical presentationHD patientsSevere malnutritionClinical benefitIncidental findingPlasmodium infectionPolymerase chain reaction