Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study
Hartley M, Hofmann N, Keitel K, Kagoro F, Moniz C, Mlaganile T, Samaka J, Masimba J, Said Z, Temba H, Gonzalez I, Felger I, Genton B, D’Acremont V. Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study. PLOS Medicine 2020, 17: e1003318. PMID: 32956354, PMCID: PMC7505590, DOI: 10.1371/journal.pmed.1003318.Peer-Reviewed Original ResearchConceptsFebrile childrenLD patientsSecondary hospitalizationCohort studyLD infectionLow-density Plasmodium infectionsMalaria rapid diagnostic testsFebrile pediatric outpatientsPlasmodium falciparum parasitemiaPrimary care levelClinical decision support algorithmPrimary care facilitiesRapid diagnostic testsHigh-density infectionsViral originPediatric outpatientsUndifferentiated feverClinical featuresClinical presentationHD patientsSevere malnutritionClinical benefitIncidental findingPlasmodium infectionPolymerase chain reaction