2017
High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients
Osman M, Benamrouz S, Guyot K, Baydoun M, Frealle E, Chabe M, Gantois N, Delaire B, Goffard A, Aoun A, Jurdi N, Dabboussi F, Even G, Slomianny C, Gosset P, Hamze M, Creusy C, Viscogliosi E, Certad G. High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients. PLOS ONE 2017, 12: e0189422. PMID: 29261714, PMCID: PMC5736188, DOI: 10.1371/journal.pone.0189422.Peer-Reviewed Original ResearchConceptsGroup of patientsLebanese patientsHuman colon cancerColon cancerColon adenocarcinomaPersistent digestive symptomsPersistent gastrointestinal symptomsRisk of infectionPotential etiological agentsPrevalence of CryptosporidiumDigestive symptomsGastrointestinal symptomsNormal biopsiesDigestive cancersColon neoplasiaDigestive biopsiesPatientsAdenocarcinomaBiopsyCancerPrevalenceEtiological agentHigh associationHuman cancersCryptosporidium prevalence
2014
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model
Benamrouz S, Conseil V, Chabé M, Praet M, Audebert C, Blervaque R, Guyot K, Gazzola S, Mouray A, Chassat T, Delaire B, Goetinck N, Gantois N, Osman M, Slomianny C, Dehennaut V, Lefebvre T, Viscogliosi E, Cuvelier C, Dei-Cas E, Creusy C, Certad G. Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and Wnt signaling in a mouse model. Disease Models & Mechanisms 2014, 7: 693-700. PMID: 24652769, PMCID: PMC4036476, DOI: 10.1242/dmm.013292.Peer-Reviewed Original ResearchConceptsHost cell biological processesCell migrationHigh-throughput sequencingHost-pathogen interactionsPotential tumorigenic roleCytoskeleton activityAnimal modelsAdherens junctionsCytoskeleton networkC. parvum-infected micePathway componentsBiological processesApicomplexan protozoaCell cycleStudied genesInfection processMetabolic pathwaysSelf-limiting diarrheaReproducible animal modelC. parvumAdult SCID miceLife-threatening diseaseΒ-cateninTumorigenic roleCryptosporidium species