2023
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance
Yassine I, Rafei R, de la Gandara M, Osman M, Fabre L, Dabboussi F, Hamze M, Weill F. Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance. Microbial Genomics 2023, 9: 001157. PMID: 38100171, PMCID: PMC10763507, DOI: 10.1099/mgen.0.001157.Peer-Reviewed Original ResearchConceptsExtended-spectrum beta-lactamase genesThird-generation cephalosporinsMultidrug resistance phenotypeBeta-lactamase genesAntimicrobial resistance determinantsPrevalent serogroupsClinical isolatesQuinolone resistanceDNA gyrase genesAntimicrobial resistanceResistance determinantsCTXResistance phenotypeAmino acid substitutionsGyrase genesIsolatesNorth LebanonFirst studyAcid substitutionsPoint mutationsGenomic analysisCephalosporins
2017
Typing and comparative genome analysis of Brucella melitensis isolated from Lebanon
Zaki N, Salloum T, Osman M, Rafei R, Hamze M, Tokajian S. Typing and comparative genome analysis of Brucella melitensis isolated from Lebanon. FEMS Microbiology Letters 2017, 364: fnx199. PMID: 28961704, DOI: 10.1093/femsle/fnx199.Peer-Reviewed Original ResearchConceptsGenome analysisLateral gene transferComparative genome analysisDraft genome sequencingWhole-genome single nucleotide polymorphism (SNP) analysisB. melitensisZoonotic disease brucellosisDepth genomic characterizationMultiple virulence determinantsSingle nucleotide polymorphism analysisNucleotide polymorphism analysisSequence divergenceGenome comparisonGenomic islandsSingle nucleotide polymorphismsGenetic variationGenomic characterizationDisease brucellosisGene transferMobile elements