Featured Publications
The indelible toll of enteric pathogens: Prevalence, clinical characterization, and seasonal trends in patients with acute community-acquired diarrhea in disenfranchised communities
Osman M, Kassem I, Dabboussi F, Cummings K, Hamze M. The indelible toll of enteric pathogens: Prevalence, clinical characterization, and seasonal trends in patients with acute community-acquired diarrhea in disenfranchised communities. PLOS ONE 2023, 18: e0282844. PMID: 36913372, PMCID: PMC10010529, DOI: 10.1371/journal.pone.0282844.Peer-Reviewed Original ResearchConceptsEnteropathogenic E. coliEnteroaggregative Escherichia coliEnterotoxigenic E. coliEnteric pathogensCross-sectional community-based studyAcute community-acquired diarrheaMultivariable logistic regression modelCommon parasitic agentsCommunity-acquired diarrheaCommunity-based studyPublic health challengeLogistic regression modelsGII infectionsAcute diarrheaMiddle-income countriesGastrointestinal PanelDiarrheic patientsEnteric infectionsOverall prevalenceRisk factorsStool samplesClinical characterizationETEC infectionDiarrheal diseaseEtiologic agent
2023
Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic
Ismail M, Zarriaa N, Osman M, Helfawi S, Kabbara N, Chatah A, Kamaleddine A, Alameddine R, Dabboussi F, Hamze M. Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic. Medicina 2023, 59: 654. PMID: 37109612, PMCID: PMC10142838, DOI: 10.3390/medicina59040654.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionMultivariable logistic regression analysisHD patientsLogistic regression analysisTuberculosis infectionDialysis unitsMulticenter cross-sectional studyQFT-Plus resultsActive tuberculosis diseaseQuantiFERON-TB GoldHospital dialysis unitRisk of mortalityTB control measuresCross-sectional studyRegression analysisCOVID-19 pandemicLow socioeconomic statusLTBI statusQFT-PlusRegular HDRegular hemodialysisElderly patientsLTBI prevalenceHemodialysis patientsPatient transmission
2020
First data on latent tuberculosis infection in Syrian refugees with diabetes in Lebanon
Ismail M, Nour D, Raad G, Osman M, Rafei R, Mallat H, Dabboussi F, Hamze M. First data on latent tuberculosis infection in Syrian refugees with diabetes in Lebanon. Public Health 2020, 189: 97-100. PMID: 33197733, DOI: 10.1016/j.puhe.2020.09.021.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionTuberculosis infectionQuantiFERON-TB GoldTuberculosis control strategiesCross-sectional studyMean ageRisk factorsClinical dataStudy populationHigh riskBlood samplesDiabetesOlder agePatientsDouble troubleInfectionVulnerable populationsAgeStructured questionnaireRiskNorth LebanonSyrian refugeesPopulationConflict-displaced populationsMellitusSpecies distribution and antifungal susceptibility patterns of clinical Candida isolates in North Lebanon: A pilot cross-sectional multicentric study
Osman M, Al Bikai A, Rafei R, Mallat H, Dabboussi F, Hamze M. Species distribution and antifungal susceptibility patterns of clinical Candida isolates in North Lebanon: A pilot cross-sectional multicentric study. Journal De Mycologie Médicale 2020, 30: 100986. PMID: 32417178, DOI: 10.1016/j.mycmed.2020.100986.Peer-Reviewed Original Research
2019
Prevalence and genetic diversity of Campylobacter spp. in the production chain of broiler chickens in Lebanon and its association with the intestinal protozoan Blastocystis sp
Greige S, Rivoal K, Osman M, Safadi D, Dabboussi F, Hage R, Viscogliosi E, Hamze M, Chemaly M. Prevalence and genetic diversity of Campylobacter spp. in the production chain of broiler chickens in Lebanon and its association with the intestinal protozoan Blastocystis sp. Poultry Science 2019, 98: 5883-5891. PMID: 31134283, DOI: 10.3382/ps/pez286.Peer-Reviewed Original ResearchConceptsHigh prevalenceCampylobacter sppBlastocystis spBroiler chickensC. coliC. jejuniBurden of campylobacteriosisC. jejuni isolatesPublic health impactHuman clinical casesPrevalence of CampylobacterSignificant associationJejuni isolatesSlaughterhouse workersClinical casesPrevalenceHuman campylobacteriosisCecumHuman gastroenteritisCampylobacter jejuniCampylobacter speciesCommon foodborne pathogensHealth impactsRecent dataTyping methodsPlasmid-mediated quinolone resistance: Mechanisms, detection, and epidemiology in the Arab countries
Yassine I, Rafei R, Osman M, Mallat H, Dabboussi F, Hamze M. Plasmid-mediated quinolone resistance: Mechanisms, detection, and epidemiology in the Arab countries. Infection Genetics And Evolution 2019, 76: 104020. PMID: 31493557, DOI: 10.1016/j.meegid.2019.104020.Peer-Reviewed Original ResearchConceptsQuinolone resistance mechanismsQuinolone resistancePlasmid-mediated quinolone resistance mechanismsPlasmid-mediated genesImportant antimicrobial classesResistance mechanismsTreatment failureEnterobacterial infectionsPMQR genesStewardship effortsAntimicrobial classesPMQRIrrational useMultiple mechanismsHigh rateEpidemiologyQuinolonesCommon associationCrucial antibioticsEnvironmental isolatesMethod of detectionEnterobacteriaceaeAntibiotic resistance genesAnimalsResistance genesMolecular epidemiology of Campylobacter isolates from broiler slaughterhouses in Tripoli, North of Lebanon
Rafei R, Kassaa I, Osman M, Dabboussi F, Hamze M. Molecular epidemiology of Campylobacter isolates from broiler slaughterhouses in Tripoli, North of Lebanon. British Poultry Science 2019, 60: 675-682. PMID: 31321996, DOI: 10.1080/00071668.2019.1645945.Peer-Reviewed Original ResearchMeSH KeywordsAbattoirsAnimalsAnti-Bacterial AgentsCampylobacterCampylobacter InfectionsCecumChickensDrug Resistance, BacterialElectrophoresis, Gel, Pulsed-FieldFlagellinFoodborne DiseasesGenetic VariationHumansLebanonPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPoultry DiseasesPrevalenceSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsAntibiotic resistance profilesErtapenem resistanceMolecular epidemiologyReal burdenResistance profilesAntibiotic resistanceRestriction fragment length polymorphismNorth of LebanonFragment length polymorphismEpidemiologyField gel electrophoresisCampylobacterLength polymorphismBroiler slaughterhousesBroilersIsolatesSlaughterhouseGentamicinAmoxicillinErythromycinFirst report on the prevalence and subtype distribution of Blastocystis sp. in dairy cattle in Lebanon and assessment of zoonotic transmission
Greige S, El Safadi D, Khaled S, Gantois N, Baydoun M, Chemaly M, Benamrouz-Vanneste S, Chabé M, Osman M, Certad G, Hamze M, Viscogliosi E. First report on the prevalence and subtype distribution of Blastocystis sp. in dairy cattle in Lebanon and assessment of zoonotic transmission. Acta Tropica 2019, 194: 23-29. PMID: 30878470, DOI: 10.1016/j.actatropica.2019.02.013.Peer-Reviewed Original ResearchConceptsDomestic cattleBlastocystis spCattle livestockDairy cattleFecal samplesLow host specificityNon-human hostsDairy farmersZoonotic potentialZoonotic transmissionCattleZoonotic reservoirsFarmers' CohortLivestockAnimal hostsST3 isolatesPossible reservoirST distributionHost specificityST10FarmsHuman populationHuman infectionsPositive samplesST1
2017
Prevalence, transmission, and host specificity of Cryptosporidium spp. in various animal groups from two French zoos
Osman M, El Safadi D, Benamrouz-Vanneste S, Cian A, Moriniere R, Gantois N, Delgado-Viscogliosi P, Guyot K, Bosc S, Chabé M, Petit T, Viscogliosi E, Certad G. Prevalence, transmission, and host specificity of Cryptosporidium spp. in various animal groups from two French zoos. Parasitology Research 2017, 116: 3419-3422. PMID: 29030716, DOI: 10.1007/s00436-017-5645-1.Peer-Reviewed Original ResearchConceptsCryptosporidium sppCaptivity animalsFrench zoosSpecies of CryptosporidiumPrevalence of CryptosporidiumFecal samplesC. galliC. tyzzeriC. andersoniCryptosporidium speciesFirst molecular studyCryptosporidium DNACryptosporidium infectionHost specificityPotential reservoirsDifferent hostsCryptosporidiumMolecular studiesZoological gardensSpeciesAnimal groupsSppAnimalsParasitesAndersoniMolecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon
Ashkar S, Osman M, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon. Journal Of Infection And Public Health 2017, 10: 745-748. PMID: 28215918, DOI: 10.1016/j.jiph.2016.11.014.Peer-Reviewed Original ResearchConceptsMacrolide resistance genotypesS. pneumoniaeMacrolide resistanceStreptococcus pneumoniaeS. pneumoniae isolatesUse of macrolidesS. pneumoniae strainsNorth LebanonResistance genotypesCMLSB phenotypePolymerase chain reactionPneumoniae isolatesPneumoniae strainsClinical isolatesPneumoniaeChain reactionEfflux pumpsPhenotypic diagnosisCommon resistance genesMolecular detectionPrevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon
Christophy R, Osman M, Mallat H, Achkar M, Ziedeh A, Moukaddem W, Dabboussi F, Hamze M. Prevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon. Journal Of Infection And Public Health 2017, 10: 716-720. PMID: 28216021, DOI: 10.1016/j.jiph.2016.10.009.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant bacteriaCancer patientsIntestinal carriageCarbapenem-resistant Gram-negative bacilliAntibiotic stewardship programsInfection control measuresDepartment of ChemotherapyGram-negative bacilliOXA-48 genePublic health concernAntimicrobial susceptibility profilesNini HospitalEndogenous infectionsMechanisms of resistanceStool samplesHigh prevalenceIntestinal floraHodge testStewardship programsPatientsAntibiotic susceptibilityNorth LebanonChemotherapySusceptibility profilesHealth concernMolecular Epidemiology of Blastocystis sp. in Various Animal Groups from Two French Zoos and Evaluation of Potential Zoonotic Risk
Cian A, Safadi D, Osman M, Moriniere R, Gantois N, Benamrouz-Vanneste S, Delgado-Viscogliosi P, Guyot K, Li L, Monchy S, Noël C, Poirier P, Nourrisson C, Wawrzyniak I, Delbac F, Bosc S, Chabé M, Petit T, Certad G, Viscogliosi E. Molecular Epidemiology of Blastocystis sp. in Various Animal Groups from Two French Zoos and Evaluation of Potential Zoonotic Risk. PLOS ONE 2017, 12: e0169659. PMID: 28060901, PMCID: PMC5217969, DOI: 10.1371/journal.pone.0169659.Peer-Reviewed Original ResearchConceptsAnimal hostsAnimal groupsFrench zoosNon-mammalian speciesNon-mammalian groupsBlastocystis spExtensive genetic diversityZoonotic transmissionNew animal hostsGenetic diversityHost specificityHuman infectionsAvian hostsPotential zoonotic riskReal-time PCRSpIntensive samplingInsectsSpeciesZoonotic riskReptilesHuman populationAnimal handlersAvian subtypesCommon intestinal parasites
2016
Alarming increase in prevalence of Neisseria gonorrhoeae infections associated with a high level of antibiotic resistance in Tripoli, Lebanon
Hamze M, Osman M, Achkar M, Mallat H, Dabboussi F. Alarming increase in prevalence of Neisseria gonorrhoeae infections associated with a high level of antibiotic resistance in Tripoli, Lebanon. International Journal Of Antimicrobial Agents 2016, 48: 576-577. PMID: 27667565, DOI: 10.1016/j.ijantimicag.2016.08.003.Peer-Reviewed Original ResearchPrevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon
Osman M, Safadi D, Cian A, Benamrouz S, Nourrisson C, Poirier P, Pereira B, Razakandrainibe R, Pinon A, Lambert C, Wawrzyniak I, Dabboussi F, Delbac F, Favennec L, Hamze M, Viscogliosi E, Certad G. Prevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon. PLOS Neglected Tropical Diseases 2016, 10: e0004496. PMID: 26974335, PMCID: PMC4790957, DOI: 10.1371/journal.pntd.0004496.Peer-Reviewed Original ResearchConceptsIntestinal protozoan infectionsProtozoan infectionsRisk factorsAssemblages of GiardiaGeneral pediatric populationPrimary risk factorCross-sectional studyPersonal hygiene habitsIntestinal pathogenic protozoaMolecular epidemiological dataLogistic regression modelsHigher infection rateSubtypes of BlastocystisDigestive symptomsPediatric populationGastrointestinal disordersAsymptomatic infectionAsymptomatic subjectsHygiene habitsOverall prevalenceStool samplesHigh prevalenceEpidemiological dataHigh riskDientamoeba fragilis
2015
Prevalence and genetic diversity of the intestinal parasites Blastocystis sp. and Cryptosporidium spp. in household dogs in France and evaluation of zoonotic transmission risk
Osman M, Bories J, Safadi D, Poirel M, Gantois N, Benamrouz-Vanneste S, Delhaes L, Hugonnard M, Certad G, Zenner L, Viscogliosi E. Prevalence and genetic diversity of the intestinal parasites Blastocystis sp. and Cryptosporidium spp. in household dogs in France and evaluation of zoonotic transmission risk. Veterinary Parasitology 2015, 214: 167-170. PMID: 26395822, DOI: 10.1016/j.vetpar.2015.09.015.Peer-Reviewed Original ResearchConceptsCryptosporidium sppHousehold dogsBlastocystis spC. canisCanine populationZoonotic transmission riskFecal samplesZoonotic riskGastrointestinal parasitesDomestic dogsZoonotic reservoirsGenetic diversityCystoisospora spGastrointestinal symptomsCommon parasiteLight microscopy examinationNatural hostOverall prevalenceSppLow prevalenceSubtype 2Giardia spIntestinal parasitesIntestinal protozoaMolecular epidemiology
2013
Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms
Safadi D, Meloni D, Poirier P, Osman M, Cian A, Gaayeb L, Wawrzyniak I, Delbac F, Alaoui H, Delhaes L, Dei-Cas E, Mallat H, Dabboussi F, Hamze M, Viscogliosi E. Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms. American Journal Of Tropical Medicine And Hygiene 2013, 88: 1203-1206. PMID: 23458955, PMCID: PMC3752823, DOI: 10.4269/ajtmh.12-0777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlastocystisBlastocystis InfectionsChildChild, PreschoolDNA, ProtozoanFecesFemaleGastrointestinal TractGenotypeHumansInfantLebanonMaleMiddle AgedMolecular EpidemiologyPrevalenceRibosome Subunits, SmallSequence Analysis, DNASpecimen HandlingYoung AdultConceptsLebanese populationCommon eukaryotic parasiteRibosomal RNA gene sequencingRNA gene sequencingAsymptomatic patientsGastrointestinal symptomsSymptomatic patientsSubtype 1Intestinal tractMolecular epidemiologyPatientsBlastocystis subtypesDirect light microscopyFecal samplesPublic healthSubtypesST distributionBlastocystis isolatesBlastocystisGene sequencingParasitesPopulationST1SymptomsEpidemiology