2023
The emergence of carbapenemase-producing Enterobacterales in hospitals: a major challenge for a debilitated healthcare system in Lebanon
Daaboul D, Oueslati S, Rima M, Kassem I, Mallat H, Birer A, Girlich D, Hamze M, Dabboussi F, Osman M, Naas T. The emergence of carbapenemase-producing Enterobacterales in hospitals: a major challenge for a debilitated healthcare system in Lebanon. Frontiers In Public Health 2023, 11: 1290912. PMID: 38074718, PMCID: PMC10699444, DOI: 10.3389/fpubh.2023.1290912.Peer-Reviewed Original ResearchConceptsKirby-Bauer disk diffusionDifferent Lebanese hospitalsSelf-medication practicesDisk diffusionPublic health systemCarbapenemase-producing EnterobacteralesConventional diagnostic methodsESBL producersHospital settingAntibiotic susceptibilityLebanese hospitalsClinical settingHospitalHealth systemSusceptibility profilesAntimicrobial resistanceHealthcare systemPlasmid typesHealthcare challengesDiagnostic methodsNDMCarbapenemsAMR awarenessIsolatesLebanese community
2021
Cl415, a carbapenem-resistant Acinetobacter baumannii isolate containing four AbaR4 and a new variant of AbGRI2, represents a novel global clone 2 strain
Liepa R, Mann R, Osman M, Hamze M, Gunawan C, Hamidian M. Cl415, a carbapenem-resistant Acinetobacter baumannii isolate containing four AbaR4 and a new variant of AbGRI2, represents a novel global clone 2 strain. Journal Of Antimicrobial Chemotherapy 2021, 77: 345-350. PMID: 34741594, PMCID: PMC8809195, DOI: 10.1093/jac/dkab399.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAminoglycosidesAnti-Bacterial AgentsCarbapenemsClone CellsPhylogenyConceptsWhole genome sequencesWide geographical distributionGene complementNovel variantsPhylogenetic analysisGenomic analysisNew lineageComplete genomeOxford NanoporeIllumina MiSeqGenetic contextResistance genesGenesAntibiotic resistance determinantsResistance phenotypeGeographical distributionCopiesAntibiotic resistance phenotypesResistance islandsGlobal distributionResistance determinantsComM geneAntibiotic resistanceSubcladesVariantsSpread of ESC-, carbapenem- and colistin-resistant Escherichia coli clones and plasmids within and between food workers in Lebanon
Al-Mir H, Osman M, Drapeau A, Hamze M, Madec J, Haenni M. Spread of ESC-, carbapenem- and colistin-resistant Escherichia coli clones and plasmids within and between food workers in Lebanon. Journal Of Antimicrobial Chemotherapy 2021, 76: 3135-3143. PMID: 34534282, DOI: 10.1093/jac/dkab327.Peer-Reviewed Original ResearchConceptsMDR E. coliCarriage rateColistin resistanceFood workersHigh carriage rateNon-duplicate isolatesMDR Escherichia coliMiddle-income countriesCarbapenem resistanceHealthy adultsE. coli lineagesDifferent STsPlasmid transmissionCarbapenemsClonal transmissionE. coliMonthly intervalsLebanese communityPlasmid spread
2020
Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital
Osman M, Halimeh F, Rafei R, Mallat H, Tom J, Raad E, Diene S, Jamal S, Al Atrouni A, Dabboussi F, Moudani W, Madec J, Saras E, Lupo A, Haenni M, Rolain J, Hamze M. Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital. Future Microbiology 2020, 15: 1535-1542. PMID: 33215520, DOI: 10.2217/fmb-2020-0079.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsBacterial ProteinsBeta-LactamasesCarbapenemsCross InfectionDisease OutbreaksDrug Resistance, Multiple, BacterialFemaleHumansIntensive Care UnitsLebanonMaleMicrobial Sensitivity TestsMiddle AgedPhylogenyTertiary Care CentersConceptsTertiary care hospitalCare hospitalPolymerase chain reactionInfection preventionPulsed-field gel electrophoresisAppropriate infection preventionIntensive care unitReal-time polymerase chain reactionMultilocus sequence typing analysisHospitalized patientsCare unitPolyclonal outbreakOXA-23Epidemiological relatednessSequence typing analysisControl measuresHospitalChain reactionFull eradicationTyping analysisPreventionOutbreakGel electrophoresisPatients