2022
The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes
Reslan L, Youssef N, Boutros C, Assaf-Casals A, Fayad D, Khafaja S, Akl F, Finianos M, Rizk A, Shaker R, Zaghlout A, Lteif M, Hafi B, Moumneh M, Feghali R, Ghanem S, Jisr T, Karayakoupoglou G, Naboulsi M, Hamze M, Samad S, Khoury E, Sarraf R, Osman M, Raad E, Amin H, Abadi I, Abdo H, Chedid M, Chamseddine F, Barakat A, Houmani M, Haddad A, Nour G, Mokhbat J, Daoud Z, El-Zaatari M, Sokhn E, Ghosn N, Ammar W, Hamadeh R, Matar G, Araj G, Dbaibo G. The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes. Expert Review Of Vaccines 2022, 21: 1905-1921. PMID: 36342411, DOI: 10.1080/14760584.2022.2143349.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseNon-vaccine typesPneumococcal conjugate vaccinePCV13 eraPneumococcal diseaseBurden of IPDSurveillance programHigher valency vaccinesPost-PCV7 eraRecommendation of vaccinationNon-vaccine serotypesImpact of vaccinationNationwide surveillance programAntimicrobial resistance profilesPCV7 eraPCV7 serotypesConjugate vaccineSerotype distributionUnvaccinated populationAntimicrobial stewardshipMortality rateAge groupsResistance profilesStudy periodSignificant decrease
2017
Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region
El Moujaber G, Osman M, Rafei R, Dabboussi F, Hamze M. Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region. Journal Of Medical Microbiology 2017, 66: 847-858. PMID: 28650313, DOI: 10.1099/jmm.0.000503.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistance, BacterialGenes, BacterialHumansMiddle EastPneumococcal InfectionsStreptococcus pneumoniaeConceptsS. pneumoniaeStreptococcus pneumoniaeDrug-resistant S. pneumoniaeAcute otitis mediaNon-invasive infectionsEmergence of multidrugEpidemiology of resistanceS. pneumoniae strainsPrevalence of resistanceMiddle Eastern countriesMolecular mechanismsOtitis mediaMechanisms of resistanceNational surveillanceAntimicrobial stewardshipEastern countriesPneumococcal strainsPneumoniae strainsHigh mortalityNasopharyngeal cavityDecreased susceptibilityCommensal bacteriumSurveillance reportsPneumoniaeAntimicrobial resistanceMolecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon
Ashkar S, Osman M, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon. Journal Of Infection And Public Health 2017, 10: 745-748. PMID: 28215918, DOI: 10.1016/j.jiph.2016.11.014.Peer-Reviewed Original ResearchConceptsMacrolide resistance genotypesS. pneumoniaeMacrolide resistanceStreptococcus pneumoniaeS. pneumoniae isolatesUse of macrolidesS. pneumoniae strainsNorth LebanonResistance genotypesCMLSB phenotypePolymerase chain reactionPneumoniae isolatesPneumoniae strainsClinical isolatesPneumoniaeChain reactionEfflux pumpsPhenotypic diagnosisCommon resistance genesMolecular detection