2022
High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa
Dabbousi A, Osman M, Dabboussi F, Hamze M. High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa. Future Microbiology 2022, 17: 957-967. PMID: 35796073, DOI: 10.2217/fmb-2021-0302.Peer-Reviewed Original ResearchConceptsHuman campylobacteriosisRoutine stool cultureBacterial gastrointestinal infectionsClinical laboratoriesIncidence of campylobacteriosisPaucity of dataMain causative agentStool culturesGastrointestinal infectionsDiarrheal patientsMicrobiological diagnosisClinical importanceFluoroquinolone resistanceInfection prevalenceAntimicrobial resistanceZoonotic diseaseCausative agentCampylobacteriosisHigh rateAlarming ratePatientsCritical needEpidemiologyInfectionPrevalenceSeroprevalence of Helicobacter pylori among dyspeptic patients in northern Lebanon: a 6-year retrospective study in two tertiary hospitals
Ismail M, Osman M, Raad E, Achkar M, Hamze M. Seroprevalence of Helicobacter pylori among dyspeptic patients in northern Lebanon: a 6-year retrospective study in two tertiary hospitals. Access Microbiology 2022, 4: 000337. PMID: 35812710, PMCID: PMC9260095, DOI: 10.1099/acmi.0.000337.Peer-Reviewed Original ResearchDyspeptic patientsRetrospective studyHospital-based retrospective studyMultivariate logistic regression analysisTertiary care centerGastric ulcer diseasePatient demographic characteristicsDemographic characteristicsAssociation of infectionConsecutive dyspeptic patientsLogistic regression analysisPrevalence of infectionNational intervention strategiesSymptomatic patientsUlcer diseaseTertiary hospitalChronic gastritisMean ageIgG antibodiesCare centerGastric cancerMale ratioStudy populationAccurate prevalencePatients
2020
Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital
Osman M, Halimeh F, Rafei R, Mallat H, Tom J, Raad E, Diene S, Jamal S, Al Atrouni A, Dabboussi F, Moudani W, Madec J, Saras E, Lupo A, Haenni M, Rolain J, Hamze M. Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital. Future Microbiology 2020, 15: 1535-1542. PMID: 33215520, DOI: 10.2217/fmb-2020-0079.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsBacterial ProteinsBeta-LactamasesCarbapenemsCross InfectionDisease OutbreaksDrug Resistance, Multiple, BacterialFemaleHumansIntensive Care UnitsLebanonMaleMicrobial Sensitivity TestsMiddle AgedPhylogenyTertiary Care CentersConceptsTertiary care hospitalCare hospitalPolymerase chain reactionInfection preventionPulsed-field gel electrophoresisAppropriate infection preventionIntensive care unitReal-time polymerase chain reactionMultilocus sequence typing analysisHospitalized patientsCare unitPolyclonal outbreakOXA-23Epidemiological relatednessSequence typing analysisControl measuresHospitalChain reactionFull eradicationTyping analysisPreventionOutbreakGel electrophoresisPatientsFirst data on latent tuberculosis infection in Syrian refugees with diabetes in Lebanon
Ismail M, Nour D, Raad G, Osman M, Rafei R, Mallat H, Dabboussi F, Hamze M. First data on latent tuberculosis infection in Syrian refugees with diabetes in Lebanon. Public Health 2020, 189: 97-100. PMID: 33197733, DOI: 10.1016/j.puhe.2020.09.021.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionTuberculosis infectionQuantiFERON-TB GoldTuberculosis control strategiesCross-sectional studyMean ageRisk factorsClinical dataStudy populationHigh riskBlood samplesDiabetesOlder agePatientsDouble troubleInfectionVulnerable populationsAgeStructured questionnaireRiskNorth LebanonSyrian refugeesPopulationConflict-displaced populationsMellitus
2019
Recent trends in the epidemiology, diagnosis, treatment, and mechanisms of resistance in clinical Aspergillus species: A general review with a special focus on the Middle Eastern and North African region
Zakaria A, Osman M, Dabboussi F, Rafei R, Mallat H, Papon N, Bouchara J, Hamze M. Recent trends in the epidemiology, diagnosis, treatment, and mechanisms of resistance in clinical Aspergillus species: A general review with a special focus on the Middle Eastern and North African region. Journal Of Infection And Public Health 2019, 13: 1-10. PMID: 31672427, DOI: 10.1016/j.jiph.2019.08.007.Peer-Reviewed Original ResearchConceptsInfectious disease specialistsSuccessful treatment outcomeIndividual patient therapyAntifungal susceptibility patternsAvailable diagnostic toolsAspergillus sppDisease specialistsAspergillus infectionMechanisms of resistanceTreatment outcomesSusceptibility patternsEarly diagnosisPatient therapyHealth workforceFungal infectionsEpidemiological surveillanceHealth issuesAntifungal resistance mechanismsHealth careAntifungal resistanceAspergillosisPatientsDiagnostic toolInfectionEpidemiologyZoonotic tuberculosis in humans assessed by next-generation sequencing: an 18-month nationwide study in Lebanon
Achkar S, Demanche C, Osman M, Rafei R, Ismail M, Gaudin C, Duthoy S, De Matos F, Yaacoub H, Pinçon C, Hamze M, Supply P. Zoonotic tuberculosis in humans assessed by next-generation sequencing: an 18-month nationwide study in Lebanon. European Respiratory Journal 2019, 55: 1900513. PMID: 31558660, DOI: 10.1183/13993003.00513-2019.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationZoonotic tuberculosisRepresentative prevalence dataLung diseaseRepresentative prevalenceNationwide studyHuman tuberculosisPrevalence dataTuberculosisMycobacterium tuberculosisHealth OrganizationMycobacterium bovisNext-generation sequencingIncome countriesAppropriate diagnosticsBurdenPatientsPrevalenceDiseaseAnimal healthEvaluation of different testing tools for the identification of non-gonococcal Neisseria spp. isolated from Lebanese male semen: a strong and significant association with infertility
Khoder M, Osman M, Diene S, Okdah L, Lalaoui R, Al Achkar M, Mallat H, Hamze M, Rolain J. Evaluation of different testing tools for the identification of non-gonococcal Neisseria spp. isolated from Lebanese male semen: a strong and significant association with infertility. Journal Of Medical Microbiology 2019, 68: 1012-1020. PMID: 31172907, DOI: 10.1099/jmm.0.000990.Peer-Reviewed Original ResearchConceptsNeisseria sppSignificant associationRetrospective study designCross-sectional retrospective study designCritical treatment decisionsSymptoms of infertilityLarge-scale epidemiological investigationsAntimicrobial susceptibility testingStrains of NeisseriaUrogenital infectionsInfertile patientsNeisseria infectionsTreatment decisionsNormal seminogramMale infertilityControl groupLebanese menEpidemiological investigationsInfertilitySusceptibility testingLebanese populationAPI NHPatientsStudy designAnalytical profile index
2017
High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients
Osman M, Benamrouz S, Guyot K, Baydoun M, Frealle E, Chabe M, Gantois N, Delaire B, Goffard A, Aoun A, Jurdi N, Dabboussi F, Even G, Slomianny C, Gosset P, Hamze M, Creusy C, Viscogliosi E, Certad G. High association of Cryptosporidium spp. infection with colon adenocarcinoma in Lebanese patients. PLOS ONE 2017, 12: e0189422. PMID: 29261714, PMCID: PMC5736188, DOI: 10.1371/journal.pone.0189422.Peer-Reviewed Original ResearchConceptsGroup of patientsLebanese patientsHuman colon cancerColon cancerColon adenocarcinomaPersistent digestive symptomsPersistent gastrointestinal symptomsRisk of infectionPotential etiological agentsPrevalence of CryptosporidiumDigestive symptomsGastrointestinal symptomsNormal biopsiesDigestive cancersColon neoplasiaDigestive biopsiesPatientsAdenocarcinomaBiopsyCancerPrevalenceEtiological agentHigh associationHuman cancersCryptosporidium prevalencePrevalence and antibiotic susceptibility patterns of bacteria causing urinary tract infections in Youssef Hospital Center: first report from Akkar governorate, North of Lebanon
Hamze M, Osman M, Mallat H, Raad E. Prevalence and antibiotic susceptibility patterns of bacteria causing urinary tract infections in Youssef Hospital Center: first report from Akkar governorate, North of Lebanon. The International Arabic Journal Of Antimicrobial Agents 2017, 7 DOI: 10.3823/0802.Peer-Reviewed Original ResearchUrinary tract infectionAntibiotic susceptibility patternHospital CenterSusceptibility patternsSusceptibility testingTract infectionsBacterial uropathogensAntibiotic resistance ratesCommon uropathogenic bacteriaAntibiotic susceptibility testingAntimicrobial susceptibility testingUTI symptomsInfected patientsRisk factorsAntibiotic resistance levelsResistance ratesEpidemiological dataUrine specimensHealthcare centersAntibiotic susceptibilityUropathogenic bacteriaProteus sppUropathogensEnterobacter sppPatientsPrevalence and antibiotic susceptibility of ear pathogens isolated from patients in Tripoli, north of Lebanon
Hamze M, Osman M, Mallat H, Achkar M. Prevalence and antibiotic susceptibility of ear pathogens isolated from patients in Tripoli, north of Lebanon. The International Arabic Journal Of Antimicrobial Agents 2017, 7 DOI: 10.3823/0801.Peer-Reviewed Original ResearchUrinary tract infectionAntibiotic susceptibility patternSusceptibility testingBacterial uropathogensSusceptibility patternsSevere public health problemAntibiotic resistance ratesPublic health problemCommon bacterial uropathogensAntibiotic susceptibility testingAntimicrobial susceptibility testingUTI symptomsTract infectionsEar pathogensInfected patientsHospital CenterAntibiotic resistance levelsResistance ratesEpidemiological dataAcinetobacter baumanniiAntibiotic susceptibilityHealth problemsPatientsProteus sppUropathogensPrevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon
Christophy R, Osman M, Mallat H, Achkar M, Ziedeh A, Moukaddem W, Dabboussi F, Hamze M. Prevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon. Journal Of Infection And Public Health 2017, 10: 716-720. PMID: 28216021, DOI: 10.1016/j.jiph.2016.10.009.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant bacteriaCancer patientsIntestinal carriageCarbapenem-resistant Gram-negative bacilliAntibiotic stewardship programsInfection control measuresDepartment of ChemotherapyGram-negative bacilliOXA-48 genePublic health concernAntimicrobial susceptibility profilesNini HospitalEndogenous infectionsMechanisms of resistanceStool samplesHigh prevalenceIntestinal floraHodge testStewardship programsPatientsAntibiotic susceptibilityNorth LebanonChemotherapySusceptibility profilesHealth concernPrevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to Youssef Hospital Center: First Report from Akkar Governorate, North Lebanon
Hamze M, Osman M, Mallat H, Achkar M. Prevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to Youssef Hospital Center: First Report from Akkar Governorate, North Lebanon. The International Arabic Journal Of Antimicrobial Agents 2017, 7 DOI: 10.3823/801.Peer-Reviewed Original Research
2015
Initial Data on the Molecular Epidemiology of Cryptosporidiosis in Lebanon
Osman M, Safadi D, Benamrouz S, Guyot K, Dei-Cas E, Aliouat E, Creusy C, Mallat H, Hamze M, Dabboussi F, Viscogliosi E, Certad G. Initial Data on the Molecular Epidemiology of Cryptosporidiosis in Lebanon. PLOS ONE 2015, 10: e0125129. PMID: 25950832, PMCID: PMC4423932, DOI: 10.1371/journal.pone.0125129.Peer-Reviewed Original ResearchConceptsMajor public health problemPublic health problemZiehl-Neelsen stainingCryptosporidium sppC. parvum subtypesGastrointestinal disordersRare subtypeImmunocompromised personsOverall prevalenceGastrointestinal tractHealth problemsFecal specimensMolecular epidemiologyEpidemiologyC. parvumPositive samplesPatientsHigh rateC. hominisInfectionPrevalenceSubtypesGp60 locusNorth LebanonCryptosporidium
2013
Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms
Safadi D, Meloni D, Poirier P, Osman M, Cian A, Gaayeb L, Wawrzyniak I, Delbac F, Alaoui H, Delhaes L, Dei-Cas E, Mallat H, Dabboussi F, Hamze M, Viscogliosi E. Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms. American Journal Of Tropical Medicine And Hygiene 2013, 88: 1203-1206. PMID: 23458955, PMCID: PMC3752823, DOI: 10.4269/ajtmh.12-0777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlastocystisBlastocystis InfectionsChildChild, PreschoolDNA, ProtozoanFecesFemaleGastrointestinal TractGenotypeHumansInfantLebanonMaleMiddle AgedMolecular EpidemiologyPrevalenceRibosome Subunits, SmallSequence Analysis, DNASpecimen HandlingYoung AdultConceptsLebanese populationCommon eukaryotic parasiteRibosomal RNA gene sequencingRNA gene sequencingAsymptomatic patientsGastrointestinal symptomsSymptomatic patientsSubtype 1Intestinal tractMolecular epidemiologyPatientsBlastocystis subtypesDirect light microscopyFecal samplesPublic healthSubtypesST distributionBlastocystis isolatesBlastocystisGene sequencingParasitesPopulationST1SymptomsEpidemiology