2024
Evaluation of SARS-CoV-2 anti-Spike antibody levels and breakthrough infection risk among vaccinated adults in North Lebanon
Nour D, Ismail M, Osman M, Rafei R, Kasir D, Dabboussi F, Colson P, Hamze M. Evaluation of SARS-CoV-2 anti-Spike antibody levels and breakthrough infection risk among vaccinated adults in North Lebanon. PLOS ONE 2024, 19: e0302579. PMID: 38722969, PMCID: PMC11081361, DOI: 10.1371/journal.pone.0302579.Peer-Reviewed Original ResearchConceptsImmune responseAntibody titersAntibody levelsAnti-spike antibody levelsCharacteristics of immune responsesWaning immune responsesMultivariate logistic regression modelSARS-CoV-2 antibody titersLevel of antibody titerVaccinated patientsBNT162b2 vaccineUnivariate analysisLogistic regression modelsSputnik V vaccineBlood specimensPfizer-BioNTechVaccine doseImmune statusVaccinated adultsSARS-CoV-2InfectionNorth LebanonVaccineAstraZeneca vaccineTiters
2023
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance
Yassine I, Rafei R, de la Gandara M, Osman M, Fabre L, Dabboussi F, Hamze M, Weill F. Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance. Microbial Genomics 2023, 9: 001157. PMID: 38100171, PMCID: PMC10763507, DOI: 10.1099/mgen.0.001157.Peer-Reviewed Original ResearchConceptsExtended-spectrum beta-lactamase genesThird-generation cephalosporinsMultidrug resistance phenotypeBeta-lactamase genesAntimicrobial resistance determinantsPrevalent serogroupsClinical isolatesQuinolone resistanceDNA gyrase genesAntimicrobial resistanceResistance determinantsCTXResistance phenotypeAmino acid substitutionsGyrase genesIsolatesNorth LebanonFirst studyAcid substitutionsPoint mutationsGenomic analysisCephalosporins
2020
First data on latent tuberculosis infection in Syrian refugees with diabetes in Lebanon
Ismail M, Nour D, Raad G, Osman M, Rafei R, Mallat H, Dabboussi F, Hamze M. First data on latent tuberculosis infection in Syrian refugees with diabetes in Lebanon. Public Health 2020, 189: 97-100. PMID: 33197733, DOI: 10.1016/j.puhe.2020.09.021.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionTuberculosis infectionQuantiFERON-TB GoldTuberculosis control strategiesCross-sectional studyMean ageRisk factorsClinical dataStudy populationHigh riskBlood samplesDiabetesOlder agePatientsDouble troubleInfectionVulnerable populationsAgeStructured questionnaireRiskNorth LebanonSyrian refugeesPopulationConflict-displaced populationsMellitusSpecies distribution and antifungal susceptibility patterns of clinical Candida isolates in North Lebanon: A pilot cross-sectional multicentric study
Osman M, Al Bikai A, Rafei R, Mallat H, Dabboussi F, Hamze M. Species distribution and antifungal susceptibility patterns of clinical Candida isolates in North Lebanon: A pilot cross-sectional multicentric study. Journal De Mycologie Médicale 2020, 30: 100986. PMID: 32417178, DOI: 10.1016/j.mycmed.2020.100986.Peer-Reviewed Original Research
2018
Molecular epidemiology of Cryptosporidium spp. in North Lebanon.
Osman M, Benamrouz S, Guyot K, El Safadi D, Mallat H, Dabboussi F, Hamze M, Viscogliosi E, Certad G. Molecular epidemiology of Cryptosporidium spp. in North Lebanon. The Journal Of Infection In Developing Countries 2018, 12: 34s. PMID: 31805009, DOI: 10.3855/jidc.10014.Peer-Reviewed Original ResearchRisk factorsFirst molecular epidemiology studySymptomatic hospitalized patientsIntestinal parasitic infectionsZiehl-Neelsen stainingMain transmission routeCryptosporidium sppMolecular epidemiology studiesGastrointestinal symptomsHospitalized patientsGastrointestinal tractParasitic infectionsEpidemiology studiesNorth LebanonPredominant causeMolecular epidemiologyChild populationFoodborne outbreaksMolecular testsCryptosporidiosisSocio-economic levelEpidemiological situationTransmission routesC. parvumFecal samplesDistribution and antibiotic susceptibility profiles of Aeromonas spp. from different aquatic environments in north Lebanon.
Rafei R, Al Kassaa I, Osman M, Dabboussi F, Hamze M. Distribution and antibiotic susceptibility profiles of Aeromonas spp. from different aquatic environments in north Lebanon. The Journal Of Infection In Developing Countries 2018, 12: 6s. PMID: 31804981, DOI: 10.3855/jidc.10055.Peer-Reviewed Original Research
2017
Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon
Ashkar S, Osman M, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon. Journal Of Infection And Public Health 2017, 10: 745-748. PMID: 28215918, DOI: 10.1016/j.jiph.2016.11.014.Peer-Reviewed Original ResearchConceptsMacrolide resistance genotypesS. pneumoniaeMacrolide resistanceStreptococcus pneumoniaeS. pneumoniae isolatesUse of macrolidesS. pneumoniae strainsNorth LebanonResistance genotypesCMLSB phenotypePolymerase chain reactionPneumoniae isolatesPneumoniae strainsClinical isolatesPneumoniaeChain reactionEfflux pumpsPhenotypic diagnosisCommon resistance genesMolecular detectionPrevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon
Christophy R, Osman M, Mallat H, Achkar M, Ziedeh A, Moukaddem W, Dabboussi F, Hamze M. Prevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon. Journal Of Infection And Public Health 2017, 10: 716-720. PMID: 28216021, DOI: 10.1016/j.jiph.2016.10.009.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant bacteriaCancer patientsIntestinal carriageCarbapenem-resistant Gram-negative bacilliAntibiotic stewardship programsInfection control measuresDepartment of ChemotherapyGram-negative bacilliOXA-48 genePublic health concernAntimicrobial susceptibility profilesNini HospitalEndogenous infectionsMechanisms of resistanceStool samplesHigh prevalenceIntestinal floraHodge testStewardship programsPatientsAntibiotic susceptibilityNorth LebanonChemotherapySusceptibility profilesHealth concernPrevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to Youssef Hospital Center: First Report from Akkar Governorate, North Lebanon
Hamze M, Osman M, Mallat H, Achkar M. Prevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to Youssef Hospital Center: First Report from Akkar Governorate, North Lebanon. The International Arabic Journal Of Antimicrobial Agents 2017, 7 DOI: 10.3823/801.Peer-Reviewed Original Research
2015
Initial Data on the Molecular Epidemiology of Cryptosporidiosis in Lebanon
Osman M, Safadi D, Benamrouz S, Guyot K, Dei-Cas E, Aliouat E, Creusy C, Mallat H, Hamze M, Dabboussi F, Viscogliosi E, Certad G. Initial Data on the Molecular Epidemiology of Cryptosporidiosis in Lebanon. PLOS ONE 2015, 10: e0125129. PMID: 25950832, PMCID: PMC4423932, DOI: 10.1371/journal.pone.0125129.Peer-Reviewed Original ResearchConceptsMajor public health problemPublic health problemZiehl-Neelsen stainingCryptosporidium sppC. parvum subtypesGastrointestinal disordersRare subtypeImmunocompromised personsOverall prevalenceGastrointestinal tractHealth problemsFecal specimensMolecular epidemiologyEpidemiologyC. parvumPositive samplesPatientsHigh rateC. hominisInfectionPrevalenceSubtypesGp60 locusNorth LebanonCryptosporidiumCharacterization of resistance genes to macrolides, lincosamides and streptogramins (MLS) among clinical isolates of Staphylococcus aureus in North Lebanon
Osman M, Nasbeh A, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Characterization of resistance genes to macrolides, lincosamides and streptogramins (MLS) among clinical isolates of Staphylococcus aureus in North Lebanon. The International Arabic Journal Of Antimicrobial Agents 2015, 5 DOI: 10.3823/780.Peer-Reviewed Original ResearchClinical isolatesStaphylococcus aureusStaphylococcus aureus infectionS. aureusPrevalence of genesMLS resistance genesMSB phenotypeNini HospitalSignificant morbidityAureus infectionDisc diffusion methodHigh prevalenceLow prevalenceMefA geneNorth LebanonPrevalenceSignificant pathogenL phenotypeResistance determinantsMLS resistanceInducible resistanceAureusErmC genePhenotypeResistance genes