2022
High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa
Dabbousi A, Osman M, Dabboussi F, Hamze M. High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa. Future Microbiology 2022, 17: 957-967. PMID: 35796073, DOI: 10.2217/fmb-2021-0302.Peer-Reviewed Original ResearchConceptsHuman campylobacteriosisRoutine stool cultureBacterial gastrointestinal infectionsClinical laboratoriesIncidence of campylobacteriosisPaucity of dataMain causative agentStool culturesGastrointestinal infectionsDiarrheal patientsMicrobiological diagnosisClinical importanceFluoroquinolone resistanceInfection prevalenceAntimicrobial resistanceZoonotic diseaseCausative agentCampylobacteriosisHigh rateAlarming ratePatientsCritical needEpidemiologyInfectionPrevalence
2021
Species distribution and antifungal susceptibility of Aspergillus clinical isolates in Lebanon
Osman M, Bidon B, Abboud C, Zakaria A, Hamze B, Achcar M, Mallat H, Dannaoui E, Dabboussi F, Papon N, Bouchara J, Hamze M. Species distribution and antifungal susceptibility of Aspergillus clinical isolates in Lebanon. Future Microbiology 2021, 16: 13-26. PMID: 33438473, DOI: 10.2217/fmb-2020-0141.Peer-Reviewed Original ResearchConceptsAntifungal susceptibilityAspergillus clinical isolatesAntifungal susceptibility patternsReverse transcription-quantitative PCRNational Reference CenterOverall drug resistanceTranscription-quantitative PCRInvasive mycosesSusceptibility patternsHealth strategiesEUCAST recommendationsReference centerClinical isolatesAmphotericin BDrug resistanceResistant isolatesMajor causeGene mutationsExpression levelsIsolatesEpidemiologySusceptibilityMycoses
2020
Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon
Rafei R, Hawli M, Osman M, Khelissa S, Salloum T, Dabboussi F, Tokajian S, Hamze M. Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon. Future Microbiology 2020, 15: 1555-1569. PMID: 33236928, DOI: 10.2217/fmb-2020-0072.Peer-Reviewed Original ResearchUpdate on invasive fungal infections in the Middle Eastern and North African region
Osman M, Al Bikai A, Rafei R, Mallat H, Dabboussi F, Hamze M. Update on invasive fungal infections in the Middle Eastern and North African region. Brazilian Journal Of Microbiology 2020, 51: 1771-1789. PMID: 32623654, PMCID: PMC7335363, DOI: 10.1007/s42770-020-00325-x.Peer-Reviewed Original Research
2019
Recent trends in the epidemiology, diagnosis, treatment, and mechanisms of resistance in clinical Aspergillus species: A general review with a special focus on the Middle Eastern and North African region
Zakaria A, Osman M, Dabboussi F, Rafei R, Mallat H, Papon N, Bouchara J, Hamze M. Recent trends in the epidemiology, diagnosis, treatment, and mechanisms of resistance in clinical Aspergillus species: A general review with a special focus on the Middle Eastern and North African region. Journal Of Infection And Public Health 2019, 13: 1-10. PMID: 31672427, DOI: 10.1016/j.jiph.2019.08.007.Peer-Reviewed Original ResearchConceptsInfectious disease specialistsSuccessful treatment outcomeIndividual patient therapyAntifungal susceptibility patternsAvailable diagnostic toolsAspergillus sppDisease specialistsAspergillus infectionMechanisms of resistanceTreatment outcomesSusceptibility patternsEarly diagnosisPatient therapyHealth workforceFungal infectionsEpidemiological surveillanceHealth issuesAntifungal resistance mechanismsHealth careAntifungal resistanceAspergillosisPatientsDiagnostic toolInfectionEpidemiologyPlasmid-mediated quinolone resistance: Mechanisms, detection, and epidemiology in the Arab countries
Yassine I, Rafei R, Osman M, Mallat H, Dabboussi F, Hamze M. Plasmid-mediated quinolone resistance: Mechanisms, detection, and epidemiology in the Arab countries. Infection Genetics And Evolution 2019, 76: 104020. PMID: 31493557, DOI: 10.1016/j.meegid.2019.104020.Peer-Reviewed Original ResearchConceptsQuinolone resistance mechanismsQuinolone resistancePlasmid-mediated quinolone resistance mechanismsPlasmid-mediated genesImportant antimicrobial classesResistance mechanismsTreatment failureEnterobacterial infectionsPMQR genesStewardship effortsAntimicrobial classesPMQRIrrational useMultiple mechanismsHigh rateEpidemiologyQuinolonesCommon associationCrucial antibioticsEnvironmental isolatesMethod of detectionEnterobacteriaceaeAntibiotic resistance genesAnimalsResistance genesMolecular epidemiology of Campylobacter isolates from broiler slaughterhouses in Tripoli, North of Lebanon
Rafei R, Kassaa I, Osman M, Dabboussi F, Hamze M. Molecular epidemiology of Campylobacter isolates from broiler slaughterhouses in Tripoli, North of Lebanon. British Poultry Science 2019, 60: 675-682. PMID: 31321996, DOI: 10.1080/00071668.2019.1645945.Peer-Reviewed Original ResearchMeSH KeywordsAbattoirsAnimalsAnti-Bacterial AgentsCampylobacterCampylobacter InfectionsCecumChickensDrug Resistance, BacterialElectrophoresis, Gel, Pulsed-FieldFlagellinFoodborne DiseasesGenetic VariationHumansLebanonPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPoultry DiseasesPrevalenceSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsAntibiotic resistance profilesErtapenem resistanceMolecular epidemiologyReal burdenResistance profilesAntibiotic resistanceRestriction fragment length polymorphismNorth of LebanonFragment length polymorphismEpidemiologyField gel electrophoresisCampylobacterLength polymorphismBroiler slaughterhousesBroilersIsolatesSlaughterhouseGentamicinAmoxicillinErythromycin
2018
Epidemiology of antimicrobial resistance in Lebanese extra-hospital settings: An overview
Osman M, Al Mir H, Rafei R, Dabboussi F, Madec J, Haenni M, Hamze M. Epidemiology of antimicrobial resistance in Lebanese extra-hospital settings: An overview. Journal Of Global Antimicrobial Resistance 2018, 17: 123-129. PMID: 30553113, DOI: 10.1016/j.jgar.2018.11.019.Peer-Reviewed Original ResearchConceptsAntimicrobial resistanceExtra-hospital settingsTerms of mortalityMiracle drugAntimicrobial-resistant pathogensNon-clinical settingsSignificant morbidityClinical settingNovel drugsAntimicrobial-resistant bacteriaMultidrug-resistant bacterial strainsSocietal costsInappropriate useCombat infectionEpidemiological situationMorbidityMortalityEpidemiologyDrugsAntibioticsVeterinary medicineAMR crisisMajority of investigationsMolecular mechanisms of antimicrobial resistance in Acinetobacter baumannii, with a special focus on its epidemiology in Lebanon
Jamal S, Al Atrouni A, Rafei R, Dabboussi F, Hamze M, Osman M. Molecular mechanisms of antimicrobial resistance in Acinetobacter baumannii, with a special focus on its epidemiology in Lebanon. Journal Of Global Antimicrobial Resistance 2018, 15: 154-163. PMID: 29859266, DOI: 10.1016/j.jgar.2018.05.022.Peer-Reviewed Original ResearchConceptsAcinetobacter baumanniiA. baumannii outbreaksIntensive care unitAntimicrobial resistanceType of infectionInternational clones ICare unitA. baumanniiHigh mortalityMolecular epidemiologyOpportunistic bacteriumBaumanniiWorldwide emergenceInfectionEpidemiologySpecific clonesMolecular mechanismsClone IMorbidityMolecular techniquesSpecial focusMortalityAvailable data
2015
Pathogenesis of Cryptosporidium in Humans
Certad G, Osman M, Benamrouz S. Pathogenesis of Cryptosporidium in Humans. 2015, 371-391. DOI: 10.1002/9781118644843.ch20.Peer-Reviewed Original ResearchCryptosporidium infectionT cell-deficient miceModulation of apoptosisT cellsImmune responseAthymic miceResistant oocystsPrecise diagnosisBarrier functionTight cell junctionsInfectionCellular damageSusceptible hostsMiceCryptosporidiumMolecular characterizationCell junctionsHumansPathogenesisEpidemiologyDiseaseDiagnosisIngestionInitial Data on the Molecular Epidemiology of Cryptosporidiosis in Lebanon
Osman M, Safadi D, Benamrouz S, Guyot K, Dei-Cas E, Aliouat E, Creusy C, Mallat H, Hamze M, Dabboussi F, Viscogliosi E, Certad G. Initial Data on the Molecular Epidemiology of Cryptosporidiosis in Lebanon. PLOS ONE 2015, 10: e0125129. PMID: 25950832, PMCID: PMC4423932, DOI: 10.1371/journal.pone.0125129.Peer-Reviewed Original ResearchConceptsMajor public health problemPublic health problemZiehl-Neelsen stainingCryptosporidium sppC. parvum subtypesGastrointestinal disordersRare subtypeImmunocompromised personsOverall prevalenceGastrointestinal tractHealth problemsFecal specimensMolecular epidemiologyEpidemiologyC. parvumPositive samplesPatientsHigh rateC. hominisInfectionPrevalenceSubtypesGp60 locusNorth LebanonCryptosporidium
2013
Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms
Safadi D, Meloni D, Poirier P, Osman M, Cian A, Gaayeb L, Wawrzyniak I, Delbac F, Alaoui H, Delhaes L, Dei-Cas E, Mallat H, Dabboussi F, Hamze M, Viscogliosi E. Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms. American Journal Of Tropical Medicine And Hygiene 2013, 88: 1203-1206. PMID: 23458955, PMCID: PMC3752823, DOI: 10.4269/ajtmh.12-0777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlastocystisBlastocystis InfectionsChildChild, PreschoolDNA, ProtozoanFecesFemaleGastrointestinal TractGenotypeHumansInfantLebanonMaleMiddle AgedMolecular EpidemiologyPrevalenceRibosome Subunits, SmallSequence Analysis, DNASpecimen HandlingYoung AdultConceptsLebanese populationCommon eukaryotic parasiteRibosomal RNA gene sequencingRNA gene sequencingAsymptomatic patientsGastrointestinal symptomsSymptomatic patientsSubtype 1Intestinal tractMolecular epidemiologyPatientsBlastocystis subtypesDirect light microscopyFecal samplesPublic healthSubtypesST distributionBlastocystis isolatesBlastocystisGene sequencingParasitesPopulationST1SymptomsEpidemiology