2023
Zoonotic Tuberculosis: A Neglected Disease in the Middle East and North Africa (MENA) Region
Kasir D, Osman N, Awik A, Ratel I, Rafei R, Al Kassaa I, Safadi D, Salma R, Omari K, Cummings K, Kassem I, Osman M. Zoonotic Tuberculosis: A Neglected Disease in the Middle East and North Africa (MENA) Region. Diseases 2023, 11: 39. PMID: 36975589, PMCID: PMC10047434, DOI: 10.3390/diseases11010039.Peer-Reviewed Original ResearchBovine tuberculosisAntimicrobial susceptibility patternsUnpasteurized dairy productsDrug-resistant strainsPrevalence of BTBSerious infectious diseasesPublic health threatAppropriate diagnostic toolsMiddle-income countriesTrue burdenCurrent treatmentSusceptibility patternsPRISMA guidelinesEffective surveillance programEtiologic agentZoonotic tuberculosisMolecular typingPoor hygieneInfectious diseasesDiseaseSurveillance programHealth threatNeglected diseaseAntimicrobial resistanceAvailable studies
2021
Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome
Osman M, Papon N. Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome. Journal Of Cellular And Molecular Medicine 2021, 25: 9473-9475. PMID: 34486221, PMCID: PMC8500950, DOI: 10.1111/jcmm.16901.Peer-Reviewed Original ResearchConceptsNrf2 pathwayOral Candida infectionCandida albicans infectionCigarette smoke compoundsImmune dysfunctionImmunosuppressive effectsNLRP3 inflammasomeOral diseasesOral mucosaCandida infectionsAlbicans infectionSmokingInfectionRelevant targetsSmoke compoundsMolecular medicineNLRP3DysfunctionMucosaInflammasomePathwayNrf2Disease
2020
Endocannabinoids Attenuate the Virulence of Certain Enteropathogenic Bacteria
Osman M, Papon N, Weill F. Endocannabinoids Attenuate the Virulence of Certain Enteropathogenic Bacteria. Trends In Microbiology 2020, 29: 185-187. PMID: 33388214, DOI: 10.1016/j.tim.2020.12.008.Peer-Reviewed Original ResearchConceptsEndocannabinoid systemInflammatory bowel diseaseIntestinal bacterial infectionsMammalian endocannabinoid systemBowel diseaseEnteric infectionsIntestinal infectionsLipid hormonesGastrointestinal physiologyBacterial infectionsEnteropathogenic bacteriaInfectionPromising targetPossible benefitsNew findingsDiseaseMiceHormoneImmunityCannabinoids
2019
Zoonotic tuberculosis in humans assessed by next-generation sequencing: an 18-month nationwide study in Lebanon
Achkar S, Demanche C, Osman M, Rafei R, Ismail M, Gaudin C, Duthoy S, De Matos F, Yaacoub H, Pinçon C, Hamze M, Supply P. Zoonotic tuberculosis in humans assessed by next-generation sequencing: an 18-month nationwide study in Lebanon. European Respiratory Journal 2019, 55: 1900513. PMID: 31558660, DOI: 10.1183/13993003.00513-2019.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationZoonotic tuberculosisRepresentative prevalence dataLung diseaseRepresentative prevalenceNationwide studyHuman tuberculosisPrevalence dataTuberculosisMycobacterium tuberculosisHealth OrganizationMycobacterium bovisNext-generation sequencingIncome countriesAppropriate diagnosticsBurdenPatientsPrevalenceDiseaseAnimal health
2015
Pathogenesis of Cryptosporidium in Humans
Certad G, Osman M, Benamrouz S. Pathogenesis of Cryptosporidium in Humans. 2015, 371-391. DOI: 10.1002/9781118644843.ch20.Peer-Reviewed Original ResearchCryptosporidium infectionT cell-deficient miceModulation of apoptosisT cellsImmune responseAthymic miceResistant oocystsPrecise diagnosisBarrier functionTight cell junctionsInfectionCellular damageSusceptible hostsMiceCryptosporidiumMolecular characterizationCell junctionsHumansPathogenesisEpidemiologyDiseaseDiagnosisIngestion