2023
Emergence of Extended-Spectrum Cephalosporin- and Colistin-Resistant Enterobacterales in Otherwise Healthy University Students
Osman M, Yassine I, Hamze M, Al Mir H, Tajani A, Bisha B, Cummings K, Madec J, Haenni M, Kassem I. Emergence of Extended-Spectrum Cephalosporin- and Colistin-Resistant Enterobacterales in Otherwise Healthy University Students. Microbial Drug Resistance 2023, 30: 101-107. PMID: 38011748, DOI: 10.1089/mdr.2023.0213.Peer-Reviewed Original ResearchLast-resort antibioticsHealthy university studentsExtended-spectrum cephalosporin-resistant isolatesComprehensive antimicrobial stewardship programAntimicrobial stewardship programsColistin-resistant isolatesExtended-spectrum cephalosporinsCephalosporin-resistant isolatesColistin-resistant EnterobacteralesMultidrug-resistant bacteriaMiddle-income countriesEvidence-based practiceAntimicrobial stewardshipStewardship programsOccurrence of resistanceCommunity settingsAntimicrobial resistanceClinical samplesAntibiotic resistanceFecal samplesResistance determinantsAntibioticsPublic healthMultiple factorsIsolates
2022
The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes
Reslan L, Youssef N, Boutros C, Assaf-Casals A, Fayad D, Khafaja S, Akl F, Finianos M, Rizk A, Shaker R, Zaghlout A, Lteif M, Hafi B, Moumneh M, Feghali R, Ghanem S, Jisr T, Karayakoupoglou G, Naboulsi M, Hamze M, Samad S, Khoury E, Sarraf R, Osman M, Raad E, Amin H, Abadi I, Abdo H, Chedid M, Chamseddine F, Barakat A, Houmani M, Haddad A, Nour G, Mokhbat J, Daoud Z, El-Zaatari M, Sokhn E, Ghosn N, Ammar W, Hamadeh R, Matar G, Araj G, Dbaibo G. The impact of vaccination on the burden of invasive pneumococcal disease from a nationwide surveillance program in Lebanon: an unexpected increase in mortality driven by non-vaccine serotypes. Expert Review Of Vaccines 2022, 21: 1905-1921. PMID: 36342411, DOI: 10.1080/14760584.2022.2143349.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseNon-vaccine typesPneumococcal conjugate vaccinePCV13 eraPneumococcal diseaseBurden of IPDSurveillance programHigher valency vaccinesPost-PCV7 eraRecommendation of vaccinationNon-vaccine serotypesImpact of vaccinationNationwide surveillance programAntimicrobial resistance profilesPCV7 eraPCV7 serotypesConjugate vaccineSerotype distributionUnvaccinated populationAntimicrobial stewardshipMortality rateAge groupsResistance profilesStudy periodSignificant decrease
2020
Update on invasive fungal infections in the Middle Eastern and North African region
Osman M, Al Bikai A, Rafei R, Mallat H, Dabboussi F, Hamze M. Update on invasive fungal infections in the Middle Eastern and North African region. Brazilian Journal Of Microbiology 2020, 51: 1771-1789. PMID: 32623654, PMCID: PMC7335363, DOI: 10.1007/s42770-020-00325-x.Peer-Reviewed Original Research
2017
Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region
El Moujaber G, Osman M, Rafei R, Dabboussi F, Hamze M. Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region. Journal Of Medical Microbiology 2017, 66: 847-858. PMID: 28650313, DOI: 10.1099/jmm.0.000503.Peer-Reviewed Original ResearchConceptsS. pneumoniaeStreptococcus pneumoniaeDrug-resistant S. pneumoniaeAcute otitis mediaNon-invasive infectionsEmergence of multidrugEpidemiology of resistanceS. pneumoniae strainsPrevalence of resistanceMiddle Eastern countriesMolecular mechanismsOtitis mediaMechanisms of resistanceNational surveillanceAntimicrobial stewardshipEastern countriesPneumococcal strainsPneumoniae strainsHigh mortalityNasopharyngeal cavityDecreased susceptibilityCommensal bacteriumSurveillance reportsPneumoniaeAntimicrobial resistance