2022
Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia
Pettigrew MM, Kwon J, Gent JF, Kong Y, Wade M, Williams DJ, Creech CB, Evans S, Pan Q, Walter EB, Martin JM, Gerber JS, Newland JG, Hofto ME, Staat MA, Fowler VG, Chambers HF, Huskins WC. Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia. MBio 2022, 13: e00195-22. PMID: 35323040, PMCID: PMC9040816, DOI: 10.1128/mbio.00195-22.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaShort-course strategyBeta-lactam therapyTreatment strategiesAntibiotic useRespiratory microbiomePediatric community-acquired pneumoniaDays of antibioticsShorter antibiotic coursesStandard-strategy groupDays of therapyStandard treatment strategyAntibiotic resistanceAdditional rationaleEffectiveness of interventionsImpact of durationAntibiotic coursesThroat swabsCourse strategyAntibiotic treatmentPediatric pneumoniaCourse treatmentLow prevalencePneumoniaAntibiotic resistance determinants
2016
Association of sputum microbiota profiles with severity of community-acquired pneumonia in children
Pettigrew MM, Gent JF, Kong Y, Wade M, Gansebom S, Bramley AM, Jain S, Arnold SL, McCullers JA. Association of sputum microbiota profiles with severity of community-acquired pneumonia in children. BMC Infectious Diseases 2016, 16: 317. PMID: 27391033, PMCID: PMC4939047, DOI: 10.1186/s12879-016-1670-4.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCAP severityMicrobiota profilesClinical courseRespiratory microbiotaPediatric community-acquired pneumoniaIntensive care unit admissionNasopharyngeal/oropharyngeal samplesCare unit admissionOdds of lengthInduced sputum samplesRespiratory tract microbiotaOP samplesRibosomal RNA sequencingUnit admissionDecreased oddsSputum samplesChildren 6Oropharyngeal samplesMicrobiota influenceChildren 5Logistic regressionSputumSeverityPneumonia