2020
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects
Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, Shankaran SS, Bisgrove BW, Demarest B, Turan N, Srivastava D, Bernstein D, Deanfield J, Giardini A, Porter G, Kim R, Roberts AE, Newburger JW, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK, Tristani-Firouzi M, Yost HJ, Ma’ayan A, Gelb BD. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC Basic To Translational Science 2020, 5: 376-386. PMID: 32368696, PMCID: PMC7188873, DOI: 10.1016/j.jacbts.2020.01.012.Peer-Reviewed Original ResearchSmall GTPaseSpecific molecular functionsWAVE2 complexMolecular functionsCHD genesSignal transductionComplex proteinsHeart disease pathogenesisCardiac developmentCausative variantsGenetic variantsGTPaseNovo variantsGenesDisease pathogenesisPrimary driverVariantsWAVE2TransductionComplexesKnockdownRegulatorProteinRegulationPathogenesis
2000
Molecular motors: the driving force behind mammalian left–right development
Supp D, Potter S, Brueckner M, Supp D, Potter S, Brueckner M. Molecular motors: the driving force behind mammalian left–right development. Trends In Cell Biology 2000, 10: 41-45. PMID: 10652513, DOI: 10.1016/s0962-8924(99)01701-8.Peer-Reviewed Original ResearchConceptsEarly vertebrate developmentMitotic spindle movementsLarge protein complexesLeft-right developmentLeft-right axisEmbryonic patterningVertebrate developmentProtein complexesCellular processesMicrotubule cytoskeletonVesicular transportSpindle movementsATP hydrolysisMolecular motorsDirectional movementCiliary beatingUnique roleCytoskeletonKinesinPatterningComplexesHydrolysis