Amelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl Cysteine: A Double-Blind, Placebo Controlled Study
Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B. Amelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl Cysteine: A Double-Blind, Placebo Controlled Study. PLOS ONE 2013, 8: e54163. PMID: 23372680, PMCID: PMC3553161, DOI: 10.1371/journal.pone.0054163.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryN-acetyl cysteineTraumatic brain injuryBrain injuryOutcome measuresPlacebo-controlled studyPlacebo Controlled StudyLong-term outcomesMain outcome measuresReported side effectsService membersActive duty service membersU.S. service membersAcute sequelaeSymptom resolutionTerm outcomesControlled StudyNAC treatmentSleep disturbancesHearing lossNeurocognitive dysfunctionBaseline evaluationCivilian mild traumatic brain injuryBlast exposurePlacebo