2014
Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis
Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Journal Of Experimental Medicine 2014, 211: 1957-1968. PMID: 25180062, PMCID: PMC4172219, DOI: 10.1084/jem.20132130.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriesCD18 AntigensDNA PrimersFlow CytometryHumansMiceMice, Inbred C57BLMonocytesNeovascularization, PhysiologicNonmuscle Myosin Type IIARac GTP-Binding ProteinsReal-Time Polymerase Chain ReactionReceptors, CCR2RNA StabilityVascular Endothelial Growth Factor AX-Ray MicrotomographyConceptsMyosin IIASignal transduction eventsHuR translocationRapid nuclearTransduction eventsProteomic analysisProtein HuR.Induction of arteriogenesisMRNA stabilityMRNA stabilizationNovel roleCytosolic translocationMyosin-9ICAM-1 adhesionReceptor engagementDevelopmental vasculogenesisCellular effectorsMolecular triggersTranslocationHeavy chainGrowth factorMyeloid cellsVascular endothelial growth factorKey molecular triggerCCL2 stimulation
2005
12/15-Lipoxygenase Regulates Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and Nuclear Factor-&kgr;B
Bolick DT, Orr AW, Whetzel A, Srinivasan S, Hatley ME, Schwartz MA, Hedrick CC. 12/15-Lipoxygenase Regulates Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and Nuclear Factor-&kgr;B. Arteriosclerosis Thrombosis And Vascular Biology 2005, 25: 2301-2307. PMID: 16166569, DOI: 10.1161/01.atv.0000186181.19909.a6.Peer-Reviewed Original ResearchMeSH Keywords12-Hydroxy-5,8,10,14-eicosatetraenoic AcidAnimalsAortaArachidonate 12-LipoxygenaseArachidonate 15-LipoxygenaseAtherosclerosisCell AdhesionEndothelium, VascularGene ExpressionIntercellular Adhesion Molecule-1MiceMice, Inbred C57BLMice, TransgenicMonocytesNF-kappa BProtein Kinase C-alphaRhoA GTP-Binding ProteinSignal TransductionVasculitisConceptsICAM-1 expressionEndothelial cellsMonocyte adhesionIntercellular adhesion molecule-1 expressionEndothelial ICAM-1 expressionAdhesion molecule-1 expressionNuclear factor-kappaB activationMolecule-1 expressionIntercellular adhesion moleculeNF-kappaB activationRho kinase inhibitor YICAM-1 inductionEndothelial intercellular adhesion moleculeAortic endothelial cellsVascular inflammationC57BL/6J controlsICAM expressionInhibition of RhoATransgenic miceActivation of RhoAHydroxyeicosatetraenoic acidNF-kappaBMRNA expressionNF-kappaB.Nuclear factor