2010
Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor
Schwartz MA. Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor. Molecular Biology Of The Cell 2010, 21: 499-500. PMID: 20150528, PMCID: PMC2820415, DOI: 10.1091/mbc.e09-07-0602.Peer-Reviewed Original Research
2008
Integrin Agonists as Adjuvants in Chemotherapy for Melanoma
Schwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson HF, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D. Integrin Agonists as Adjuvants in Chemotherapy for Melanoma. Clinical Cancer Research 2008, 14: 6193-6197. PMID: 18829498, DOI: 10.1158/1078-0432.ccr-08-1285.Peer-Reviewed Original ResearchConceptsMelanoma linesExtracellular matrixMetastatic melanomaM21 tumorsTherapeutic responseImmunodeficient miceTumor volumeChemotherapyClonal growth assaysTherapy resistanceTumor growthHuman melanomaChemotherapeutic efficacyMelanomaTumor cellsDrug 1Survival assaysM21 cellsM21 melanomaSmall nestsIntegrin agonistsIntegrin-dependent adhesionTumorsMiceSnake venom
2003
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
Truong T, Sun G, Doorly M, Wang JY, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 10281-10286. PMID: 12928501, PMCID: PMC193552, DOI: 10.1073/pnas.1635435100.Peer-Reviewed Original ResearchConceptsC-Abl/p73 pathwayDNA damageIntegrin ligationC-AblDNA damage-induced apoptosisC-Abl tyrosine kinaseCell adhesionExtracellular matrixDamage-induced apoptosisP73 pathwayCertain cell typesP53-negative tumor cellsProapoptotic transcription factorTranscription factorsTyrosine kinaseApoptotic responseDifferential utilizationCell typesDifferent tumor cell linesTumor cell linesTumor cellsP53 levelsCell linesSecond pathwayCell killing
2002
Integrins regulate the apoptotic response to DNA damage through modulation of p53
Lewis JM, Truong TN, Schwartz MA. Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3627-3632. PMID: 11904424, PMCID: PMC122574, DOI: 10.1073/pnas.062698499.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesApoptosisCaspase 3CaspasesCell AdhesionCell SurvivalChromosome AberrationsCyclin-Dependent Kinase Inhibitor p16DNA DamageFibroblastsHumansIntegrinsMelanomaMiceMutationNuclear ProteinsOrgan SpecificityProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Radiation, IonizingSarcomaTumor Cells, CulturedTumor Suppressor Protein p14ARFTumor Suppressor Protein p53ConceptsTumor cellsTherapy-resistant tumorsModulation of p53Susceptible tumor cellsDNA damageLevels of p53Low p53 levelsApoptosis of cellsTherapy resistanceAntiintegrin antibodiesCancer cellsP53 levelsSurvival of cellsP53Nonadherent cellsCell typesSurvivalApoptotic responseCellsP19 ARFApoptosisChromosomal instabilityFibroblastic cell typesDamageChemotherapy
1993
The extracellular matrix as a cell survival factor.
Meredith J, Fazeli B, Schwartz M. The extracellular matrix as a cell survival factor. Molecular Biology Of The Cell 1993, 4: 953-961. PMID: 8257797, PMCID: PMC275725, DOI: 10.1091/mbc.4.9.953.Peer-Reviewed Original ResearchConceptsCell survival factorExtracellular matrixCell typesSurvival factorCell deathTyrosine phosphatase inhibitor sodium orthovanadateCell suicide pathwayRapid cell deathSuicide pathwayECM interactionsDNA degradationHuman endothelial cellsSodium orthovanadateCell growthPCDNucleus fragmentationTRPM-2Cell morphologyVascular cell adhesion molecule-1Class I histocompatibility antigenCell viabilityGrowth factorSpecific hormonesEndothelial cellsPotential role