Vascular Mechanobiology: Homeostasis, Adaptation, and Disease
Humphrey JD, Schwartz MA. Vascular Mechanobiology: Homeostasis, Adaptation, and Disease. Annual Review Of Biomedical Engineering 2021, 23: 1-27. PMID: 34255994, PMCID: PMC8719655, DOI: 10.1146/annurev-bioeng-092419-060810.Peer-Reviewed Original ResearchConceptsArterial healthDisease progressionVascular wallTherapeutic needsHealthy vesselsHomeostatic mechanismsDiseaseVessel wallHomeostatic pathwaysPositive feedback loopWall mechanicsHomeostasisGene expressionOptimal functionMajor diseasesNegative feedback loopRegulatory pathwaysInflammationBiochemical meansArtery