2014
Spatial and temporal control of Rho GTPase functions
Moissoglu K, Schwartz MA. Spatial and temporal control of Rho GTPase functions. Cellular Logistics 2014, 4: e943618. PMID: 25610718, PMCID: PMC4279778, DOI: 10.4161/21592780.2014.943618.Peer-Reviewed Original ResearchCellular compartmentsRho GTPase biologyRho GTPases functionRho GTPase functionMultiple cellular compartmentsDifferent cellular compartmentsTemporal controlGTPase inactivationMembrane targetingGTPases functionGTPase functionCellular functionsRho GTPaseCell physiologyBiochemical regulationEffector activationMultiple regulatorsMultiple effectorsWealth of knowledgeSame cellsRegulationCompartmentsNano-scale dynamicsGTPaseMajor questions
2004
Integrins Regulate Rac Targeting by Internalization of Membrane Domains
del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA. Integrins Regulate Rac Targeting by Internalization of Membrane Domains. Science 2004, 303: 839-842. PMID: 14764880, DOI: 10.1126/science.1092571.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell AdhesionCell LineCell MembraneCells, CulturedCholera ToxinCholesterolG(M1) GangliosideGlycosylphosphatidylinositolsGuanosine TriphosphateHumansIntegrin beta1IntegrinsLiposomesMembrane MicrodomainsMiceNIH 3T3 CellsRac1 GTP-Binding ProteinRatsRecombinant Fusion ProteinsSignal TransductionTransfectionConceptsMembrane domainsLipid raftsLipid raft markersPlasma membrane cholesterolCholesterol-rich membranesCell plasma membraneMembrane targetingAdhesion of cellsSmall GTPRaft markersIntegrin signalsPlasma membraneDownstream effectorsEffector activationMembrane lipidsMembrane cholesterolAnchorage-dependent cellsExtracellular matrixCell detachmentNonadherent cellsInternalizationRaftsCellsTargetingMembrane