2018
Gut commensal-dependent production of autoantibodies against the primordial lupus autoantigen Ro60 in the absence of mammalian Ro60.
Datta R, Dehner C, Ruff W, Greiling T, Kriegel M. Gut commensal-dependent production of autoantibodies against the primordial lupus autoantigen Ro60 in the absence of mammalian Ro60. The Journal Of Immunology 2018, 200: 162.11-162.11. DOI: 10.4049/jimmunol.200.supp.162.11.Peer-Reviewed Original ResearchAnti-Ro60 autoantibodiesSystemic lupus erythematosusB6 miceGut microbiotaSLE-like diseaseTraditional risk factorsDevelopment of lupusBroad-spectrum antibioticsMurine gut microbiotaLupus erythematosusAntigenic triggerAutoimmune responseTg miceInterventional studyKO miceRisk factorsIgG ELISAAutoantibody inductionDisease manifestationsOral administrationT cellsAutoantibodiesMiceRo60LupusPrevention of systemic autoimmunity by dietary modulation of the gut microbiota
Ruiz D, El-Beidaq A, Iniguez A, di Ricco M, Mubiro D, Vieira S, Ruff W, Sterpka J, Kriegel M. Prevention of systemic autoimmunity by dietary modulation of the gut microbiota. The Journal Of Immunology 2018, 200: 54.1-54.1. DOI: 10.4049/jimmunol.200.supp.54.1.Peer-Reviewed Original ResearchSystemic lupus erythematosusType I interferonShort-chain fatty acidsI interferonB6 miceTg miceAutoimmune diseasesGut microbiotaHuman systemic lupus erythematosusDendritic cell accumulationImmune-microbiota interactionsPrototypical autoimmune diseaseOnset of diseaseAmeliorate autoimmunityLupus inductionLupus manifestationsKidney involvementLupus pathogenesisLupus erythematosusTLR7 agonistSystemic autoimmunityPeyer's patchesDietary modulationCell accumulationGut microbial community
2017
Commensal Ro60 Orthologs as Persistent Triggers of Human Lupus
Dehner C, Greiling T, Chen X, Renfroe S, Hughes K, Vieira S, Ruff W, Boccitto M, Sim S, Chen X, Kriegel C, Degnan P, Goodman A, Wolin S, Kriegel M. Commensal Ro60 Orthologs as Persistent Triggers of Human Lupus. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.55.3.Peer-Reviewed Original ResearchMesenteric lymph nodesSystemic lupus erythematosusT cell clonesLupus patientsSLE patientsTg miceAutoimmune diseasesMicrobial triggersCell clonesT cellsGerm-free (GF) C57BL/6 miceP. propionicumMemory CD4 T cellsHuman SLE seraPrototypical autoimmune diseaseCD4 T cellsHuman autoimmune diseasesGerm-free miceAnti-Ro60 antibodiesEarliest autoantibodiesRo60 antibodiesLupus modelsLupus erythematosusLymph nodesHuman lupus