Gut commensal-dependent production of autoantibodies against the primordial lupus autoantigen Ro60 in the absence of mammalian Ro60.
Datta R, Dehner C, Ruff W, Greiling T, Kriegel M. Gut commensal-dependent production of autoantibodies against the primordial lupus autoantigen Ro60 in the absence of mammalian Ro60. The Journal Of Immunology 2018, 200: 162.11-162.11. DOI: 10.4049/jimmunol.200.supp.162.11.Peer-Reviewed Original ResearchAnti-Ro60 autoantibodiesSystemic lupus erythematosusB6 miceGut microbiotaSLE-like diseaseTraditional risk factorsDevelopment of lupusBroad-spectrum antibioticsMurine gut microbiotaLupus erythematosusAntigenic triggerAutoimmune responseTg miceInterventional studyKO miceRisk factorsIgG ELISAAutoantibody inductionDisease manifestationsOral administrationT cellsAutoantibodiesMiceRo60Lupus