2021
Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions
Dehner CA, Ruff WE, Greiling T, Pereira MS, Redanz S, McNiff J, Girardi M, Kriegel MA. Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions. JID Innovations 2021, 2: 100084. PMID: 35199089, PMCID: PMC8844718, DOI: 10.1016/j.xjidi.2021.100084.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT cell activationSkin microbiotaAppropriate genetic backgroundCell activationBacillus speciesCutaneous T-cell lymphoma lesionsUnique microbiotaHuman commensalGenetic backgroundCell explantsClonal T-cell proliferationSkin-homing CD4T-cell lymphomaAdaptive immune responsesCell interactionsT cell proliferationT cell interactionsEnvironmental factorsMicrobial triggersMicrobiotaCommensalCTCL lesionsLymphoma lesionsCytokine secretionChapter 25 Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome
Greiling T, Vieira S, Kriegel M. Chapter 25 Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome. 2021, 211-221. DOI: 10.1016/b978-0-12-814551-7.00025-8.Peer-Reviewed Original ResearchSystemic lupus erythematosusSjögren's syndromeLupus erythematosusSystemic autoimmunityAdaptive immune responsesPathogenesis of autoimmunityToll-like receptorsProne hostsBarrier organsImmune responseAdaptive immunityInnate triggersAnimal modelsMicrobiota influenceCommensal bacteriaSyndromeMucus membranesAutoimmunityHuman autoantigensErythematosusPathogenesisMicrobiotaLive bacteriaHost tissuesInflammationChapter 9 Immunopathogenesis: the role of mucosal and skin microbiota in SLE
Greiling T, Kriegel M. Chapter 9 Immunopathogenesis: the role of mucosal and skin microbiota in SLE. 2021, 117-130. DOI: 10.1016/b978-0-12-820583-9.00012-9.Peer-Reviewed Original Research
2020
Host–microbiota interactions in immune-mediated diseases
Ruff WE, Greiling TM, Kriegel MA. Host–microbiota interactions in immune-mediated diseases. Nature Reviews Microbiology 2020, 18: 521-538. PMID: 32457482, DOI: 10.1038/s41579-020-0367-2.Peer-Reviewed Original ResearchConceptsImmune-mediated diseasesHost-microbiota interactionsImmune systemChronic inflammatory disordersSkin microbiotaHost immune systemProne hostsImmune toleranceInflammatory disordersTherapeutic avenuesDiseaseHost-microorganism interactionsMicrobiotaGnotobiotic modelsMolecular mechanismsBarrier surfacesNew studiesUrgent needMucosal
2015
Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740)
Manfredo Vieira S, Ruff W, Hiltensperger M, Yu A, Goodman A, Kriegel M. Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740). The Journal Of Immunology 2015, 194: 205.4-205.4. DOI: 10.4049/jimmunol.194.supp.205.4.Peer-Reviewed Original ResearchAntiphospholipid syndromeSegmented filamentous bacteriaSystemic autoimmunityGut microbiotaAntiphospholipid antibody productionRegulatory IL-10Gut microbiota compositionAntigen-specific effectsBroad-spectrum antibioticsAnaerobic gut microbiotaTh17 cellsIL-17Infectious triggerPathogenic autoantibodiesPulmonary emboliIL-10IL-21Myocardial infarctionIL-1BSplenocyte proliferationAntibody productionMicrobiota compositionImmune systemAutoimmunityMicrobiotaAutoimmune host–microbiota interactions at barrier sites and beyond
Ruff WE, Kriegel MA. Autoimmune host–microbiota interactions at barrier sites and beyond. Trends In Molecular Medicine 2015, 21: 233-244. PMID: 25771098, PMCID: PMC5918312, DOI: 10.1016/j.molmed.2015.02.006.Peer-Reviewed Original ResearchConceptsBarrier sitesAutoimmune animal modelsPathogenesis of autoimmunityBystander activationHost-microbiota interactionsAutoimmune diseasesAdaptive immunityAnimal modelsInfectious agentsAutoimmunityGnotobiotic approachesHomeostatic conditionsInternal organsCurrent literatureMicrobiotaDetrimental effectsHuman microbiome studiesDysbiosisPathogenesisMicrobiome studiesDiseaseImmunity