Nicotine and food deprivation decrease the ability to resist smoking
Leeman RF, O’Malley S, White MA, McKee SA. Nicotine and food deprivation decrease the ability to resist smoking. Psychopharmacology 2010, 212: 25-32. PMID: 20585761, PMCID: PMC3111597, DOI: 10.1007/s00213-010-1902-z.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingNicotine deprivationAd libitum smokingFood deprivationSmoking lapse behaviorSelf-administration periodEffect of foodSmokers' abilityMore cigarettesFirst cigaretteHuman laboratory paradigmDaily smokersTobacco cravingFood intakeCessation failureSmokingConclusionsThese findingsFood cuesMonetary reinforcementCigarettesNicotineSex differencesDeprivationLaboratory sessionsOutcomesLow-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: A randomized trial
Toll BA, White M, Wu R, Meandzija B, Jatlow P, Makuch R, O’Malley S. Low-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: A randomized trial. Drug And Alcohol Dependence 2010, 111: 200-206. PMID: 20542391, PMCID: PMC3771701, DOI: 10.1016/j.drugalcdep.2010.04.015.Peer-Reviewed Original ResearchConceptsWeight gainSmoking cessationPoint prevalence smoking abstinence ratePre-specified primary outcomesLow-dose naltrexoneOpen-label therapySmoking abstinence ratesPoint prevalence abstinenceReduced weight gainNaltrexone augmentationPlacebo groupNicotine replacementPrimary outcomeQuit dateAbstinence ratesLabel therapyNicotine patchBehavioral counselingNaltrexoneAbstinent participantsSmokersWeight concernsWeeksCessationLower rates