2022
Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial
Fang X, Davis X, Flack KD, Duncan C, Li F, White M, Grilo C, Small DM. Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial. Frontiers In Nutrition 2022, 9: 940064. PMID: 35967820, PMCID: PMC9369668, DOI: 10.3389/fnut.2022.940064.Peer-Reviewed Original ResearchWeight loss maintenanceHigh-fat dietWeight loss treatmentLoss maintenanceWeight lossLoss treatmentStandard behavioral weight loss treatmentShort-term weight lossBehavioral weight loss interventionBehavioral weight loss treatmentGut-brain pathwaysPlacebo-controlled trialGut-brain axisVagal afferent pathwaysGut-brain signalingDietary fat intakeOverweight/obesityWeight loss interventionPrecision medicine approachEnergy-dense foodsLoss interventionFat intakeAfferent pathwaysHabitual intakeMetabolic healthEthnic and racial comparisons of weight-loss treatment utilization history and outcomes in patients with obesity and binge-eating disorder
Coffino JA, Ivezaj V, Barnes RD, White MA, Pittman BP, Grilo CM. Ethnic and racial comparisons of weight-loss treatment utilization history and outcomes in patients with obesity and binge-eating disorder. Eating Behaviors 2022, 44: 101594. PMID: 35123375, PMCID: PMC8888034, DOI: 10.1016/j.eatbeh.2021.101594.Peer-Reviewed Original ResearchConceptsBinge-eating disorderTreatment utilizationWeight lossNon-Hispanic white patientsNon-white patientsMental health servicesNon-Hispanic whitesTreatment-seeking patientsType of dietWhite patientsMinority patientsPatientsObesityReported utilizationNon-significant differenceEthnicity/raceRacial differencesDietRacial comparisonsSignificant differencesTreatmentDisordersUtilization historyAdultsOutcomes
2021
Physical activity changes during behavioral weight loss treatment by Latinx patients with obesity with and without binge eating disorder
Grilo CM, Kerrigan SG, Lydecker JA, White MA. Physical activity changes during behavioral weight loss treatment by Latinx patients with obesity with and without binge eating disorder. Obesity 2021, 29: 2026-2034. PMID: 34582624, PMCID: PMC8612949, DOI: 10.1002/oby.23278.Peer-Reviewed Original ResearchConceptsBehavioral weight loss treatmentWeight loss treatmentLatinx patientsPhysical activity changesBWL treatmentReduced depressionCommunity mental health centerWeight lossPA changePlacebo-controlled trialAddition of orlistatMental health centersActivity changesPrognostic significanceMedication conditionHealth centersLoss treatmentPatientsObesitySecondary analysisClinical settingBed statusBaselineTreatmentDepression
2020
Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge‐Eating Disorder: 12‐Month Follow‐up
Grilo CM, White MA, Ivezaj V, Gueorguieva R. Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge‐Eating Disorder: 12‐Month Follow‐up. Obesity 2020, 28: 2116-2124. PMID: 32985114, PMCID: PMC7644623, DOI: 10.1002/oby.22975.Peer-Reviewed Original ResearchConceptsBehavioral weight lossStepped careWeight lossWeight loss medicationsRandomized Controlled TrialsSignificant weight lossBinge-eating disorderBinge-eating frequencySignificant time effectBinge Eating DisorderCognitive behavioral therapyRemission rateControlled TrialsTreatment respondersLong-term effectsBehavioral therapyMixed modelsPatientsCareObesitySignificant reductionTreatmentMonthsPosttreatmentDisordersRandomized Controlled Trial Testing the Effectiveness of Adaptive “SMART” Stepped-Care Treatment for Adults With Binge-Eating Disorder Comorbid With Obesity
Grilo CM, White MA, Masheb RM, Ivezaj V, Morgan PT, Gueorguieva R. Randomized Controlled Trial Testing the Effectiveness of Adaptive “SMART” Stepped-Care Treatment for Adults With Binge-Eating Disorder Comorbid With Obesity. American Psychologist 2020, 75: 204-218. PMID: 32052995, PMCID: PMC7027689, DOI: 10.1037/amp0000534.Peer-Reviewed Original ResearchConceptsStepped-care treatmentCognitive behavioral therapyWeight loss medicationsBinge-eating disorderStepped careRemission rateWeight lossBehavioral weight lossSignificant weight lossBinge-eating frequencySignificant time effectControlled TrialsTreat analysisTreatment respondersMedicationsPlaceboMixed model analysisClinical practiceNonrespondersPatientsObesityBinge eatingCareMonthsTreatment
2019
Examining sex as a predictor and moderator of treatment outcomes for binge‐eating disorder: Analysis of aggregated randomized controlled trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining sex as a predictor and moderator of treatment outcomes for binge‐eating disorder: Analysis of aggregated randomized controlled trials. International Journal Of Eating Disorders 2019, 53: 20-30. PMID: 31497876, PMCID: PMC6983351, DOI: 10.1002/eat.23167.Peer-Reviewed Original ResearchConceptsBinge-eating disorderEating-disorder psychopathologyCognitive behavioral therapySelf-report measuresModerators of outcomeTreatment outcomesBehavioral weight lossStatistical Manual-Fourth EditionSignificant moderatorWeight lossControl conditionModeratorCourse of treatmentBetter treatment outcomesGreater weight lossMain effectStructured interviewsTreatment settingsPsychopathologyMultimodal treatmentPatient groupRCT studiesMedical CenterBed treatmentParticipantsExamining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials. Journal Of Consulting And Clinical Psychology 2019, 87: 530-540. PMID: 31008634, PMCID: PMC6589831, DOI: 10.1037/ccp0000404.Peer-Reviewed Original ResearchConceptsBinge-eating disorderWhite participantsCognitive behavioral therapySelf-report measuresTreatment outcomesBinge-eating remissionModerate treatment outcomeBinge Eating DisorderBinge-eating episodesMain effectBlack participantsWeight lossBehavioral weight lossEvidence-based treatmentsLower depressionTreatment researchRandomized Controlled TrialsBetter treatment outcomesControl conditionParticipantsControlled TrialsMultimodal treatmentPercent weight lossPatient groupModerator
2016
Loss-of-control eating following sleeve gastrectomy surgery
Ivezaj V, Kessler EE, Lydecker JA, Barnes RD, White MA, Grilo CM. Loss-of-control eating following sleeve gastrectomy surgery. Surgery For Obesity And Related Diseases 2016, 13: 392-398. PMID: 27913121, PMCID: PMC5357454, DOI: 10.1016/j.soard.2016.09.028.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionPoorer weight loss outcomesBED criteriaLower percent weight lossPoor weight lossWeight loss outcomesBody mass indexEating-disorder psychopathologyBinge-eating disorderRegular compensatory behaviorsCurrent mean ageUnited States METHODSBariatric surgeryPostoperative lossMass indexPercent weight lossMean ageMonths postsurgeryPoor outcomeLoss outcomesGreater severitySurgery
2015
Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study
White MA, Kalarchian MA, Levine MD, Masheb RM, Marcus MD, Grilo CM. Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study. Obesity Surgery 2015, 25: 1909-1916. PMID: 25720515, PMCID: PMC4551611, DOI: 10.1007/s11695-015-1631-9.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryPostoperative depressive symptomsElevated depressive symptomsDepressive symptomsBypass surgeryWeight outcomesPrognostic significanceDisorder psychopathologyLong-term weight outcomesWeight lossPoorer weight outcomesPreoperative depressive symptomsBariatric surgery patientsWeight loss outcomesSignificant depressive symptomsMethodsThree hundred fiftyQuality of lifeBeck Depression InventorySurgery patientsBattery of assessmentsHundred fiftyLoss outcomesBackgroundThis studySurgeryClinical attention
2014
A randomized controlled trial comparing scalable weight loss treatments in primary care
Barnes RD, White MA, Martino S, Grilo CM. A randomized controlled trial comparing scalable weight loss treatments in primary care. Obesity 2014, 22: 2508-2516. PMID: 25298016, PMCID: PMC4236282, DOI: 10.1002/oby.20889.Peer-Reviewed Original ResearchConceptsNutrition psychoeducationUsual careAttention control interventionMotivational interviewingTreatment adherenceWeight lossOverweight/obese patientsBed statusWeight loss outcomesPrimary care settingWeight loss treatmentWeight loss resultsObese patientsTriglyceride levelsPrimary careObesity interventionsNPC patientsLoss outcomesLoss treatmentDepression scoresScalable interventionsPatientsTreatment disseminationSuperior benefitsInterventionTreatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: Randomized placebo-controlled clinical trial of self-help and medication
Grilo CM, Masheb RM, White MA, Gueorguieva R, Barnes RD, Walsh BT, McKenzie KC, Genao I, Garcia R. Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: Randomized placebo-controlled clinical trial of self-help and medication. Behaviour Research And Therapy 2014, 58: 1-9. PMID: 24857821, PMCID: PMC4074556, DOI: 10.1016/j.brat.2014.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Obesity AgentsBinge-Eating DisorderBlack or African AmericanBody WeightCognitive Behavioral TherapyCombined Modality TherapyCyclobutanesDouble-Blind MethodFemaleHispanic or LatinoHumansMaleMiddle AgedObesityPrimary Health CareSelf CareTime FactorsTreatment OutcomeWhite PeopleYoung AdultConceptsSelf-help cognitive behavioral therapyDiverse obese patientsAnti-obesity medicationsObese patientsModerate clinical outcomePercent weight lossTime interaction effectsWeight lossClinical outcomesPrimary careRandomized placebo-controlled clinical trialSecond placebo-controlled trialPlacebo-controlled clinical trialAcute weight lossPlacebo-controlled trialDouble-blind fashionDiscontinuation of medicationPrimary care settingWeight loss maintenanceSpecialist treatment centresTreatment of bingeDiverse patient groupsSelf-help CBTBinge-eating frequencyDemographic factors
2013
Self-help for binge eating disorder in primary care: A randomized controlled trial with ethnically and racially diverse obese patients
Grilo CM, White MA, Gueorguieva R, Barnes RD, Masheb RM. Self-help for binge eating disorder in primary care: A randomized controlled trial with ethnically and racially diverse obese patients. Behaviour Research And Therapy 2013, 51: 855-861. PMID: 24189569, PMCID: PMC3863907, DOI: 10.1016/j.brat.2013.10.002.Peer-Reviewed Original ResearchConceptsDiverse obese patientsUsual careObese patientsSelf-help CBTPrimary careEating Disorder ExaminationPrimary care interventionsPrimary care settingSelf-help versionFour-month treatmentSelf-help treatmentFront-line interventionCognitive behavioral therapyRemission rateMixed modelsCare interventionsCare settingsPatientsGeneralist settingsBehavioral therapyDisorder ExaminationDisorder psychopathologyWeight lossBingeCareSubstantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder
Masheb RM, White MA, Grilo CM. Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. Comprehensive Psychiatry 2013, 54: 880-884. PMID: 23639407, PMCID: PMC3779527, DOI: 10.1016/j.comppsych.2013.03.017.Peer-Reviewed Original ResearchConceptsObese patientsBody weightWeight gainWeight gainersWeight lossHigh weight gainersLow weight gainersModest weight lossWeight changePercent of treatmentsFurther weight gainSubstantial weight gainObese BED patientsStabilization of weightTreatment-seeking obese patientsTreatment initiationSelf-report questionnairesBED patientsPatientsWeight trajectoriesCurrent weightTreatment studiesDisorder psychopathologyPercent weight gainMean gainBupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial.
White MA, Grilo CM. Bupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial. The Journal Of Clinical Psychiatry 2013, 74: 400-6. PMID: 23656848, PMCID: PMC4021866, DOI: 10.4088/jcp.12m08071.Peer-Reviewed Original ResearchConceptsBinge-eating disorderPlacebo-controlled trialObese womenOutcome measuresWeight lossDSM-IV-TR research criteriaTreatment of BEDInappropriate weight compensatory behaviorsRandomized placebo-controlled trialShort-term weight lossFood cravingsPercent BMI lossSecondary outcome measuresPrimary outcome measureShort-term efficacyTerm weight lossBinge-eating frequencySignificant time effectStand-alone treatmentLong-term trialsBMI lossPlacebo groupLifestyle interventionOverweight womenRandomized participantsOrlistat with behavioral weight loss for obesity with versus without binge eating disorder: Randomized placebo-controlled trial at a community mental health center serving educationally and economically disadvantaged Latino/as
Grilo CM, White MA. Orlistat with behavioral weight loss for obesity with versus without binge eating disorder: Randomized placebo-controlled trial at a community mental health center serving educationally and economically disadvantaged Latino/as. Behaviour Research And Therapy 2013, 51: 167-175. PMID: 23376451, PMCID: PMC3666334, DOI: 10.1016/j.brat.2013.01.002.Peer-Reviewed Original ResearchConceptsCommunity mental health centerMental health centersPlacebo-controlled trialBehavioral weight lossAddition of orlistatHealth centersRandomized placebo-controlled trialTreatment studiesWeight lossComplex patient groupNon-BED groupObesity Treatment StudyNegative prognostic indicatorHigh rateModerate treatment outcomeRemission rateObese patientsPlacebo medicationDiabetes preventionMixed-model analysisPatient groupObesity treatmentPrognostic indicatorTreatment outcomesEfficacy trials
2011
Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial
Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial. Journal Of Consulting And Clinical Psychology 2011, 79: 675-685. PMID: 21859185, PMCID: PMC3258572, DOI: 10.1037/a0025049.Peer-Reviewed Original ResearchConceptsPercent BMI lossBehavioral weight lossBinge-eating disorderCognitive behavioral therapyBMI lossObese patientsWeight lossBinge-eating remissionAlternative treatment optionBinge Eating DisorderRemission rateControlled TrialsTreatment optionsMixed model analysisBehavioral therapyPatientsManualized treatmentAssessment pointsBingeRemissionGreater reductionTreatmentTherapySequential treatmentDisordersRapid response predicts 12-month post-treatment outcomes in binge-eating disorder: theoretical and clinical implications
Grilo CM, White MA, Wilson GT, Gueorguieva R, Masheb RM. Rapid response predicts 12-month post-treatment outcomes in binge-eating disorder: theoretical and clinical implications. Psychological Medicine 2011, 42: 807-817. PMID: 21923964, PMCID: PMC3288595, DOI: 10.1017/s0033291711001875.Peer-Reviewed Original ResearchConceptsBehavioral weight lossBinge-eating disorderCognitive behavioral therapyWeight lossPrognostic significanceClinical implicationsShort-term weight lossDisorder psychopathologyBinge-eating remissionStepped-care modelDifferent prognostic significanceNon-rapid respondersMost baseline variablesPost-treatment outcomesBinge-eating frequencyObese patientsBaseline variablesDistinct time coursesClinical trialsInitial interventionRapid respondersWeek fourBehavioral therapySpecialized treatmentPatients
2010
Physical Activity in Gastric Bypass Patients: Associations with Weight Loss and Psychosocial Functioning at 12-Month Follow-Up
Rosenberger PH, Henderson KE, White MA, Masheb RM, Grilo CM. Physical Activity in Gastric Bypass Patients: Associations with Weight Loss and Psychosocial Functioning at 12-Month Follow-Up. Obesity Surgery 2010, 21: 1564-1569. PMID: 20890771, PMCID: PMC3652016, DOI: 10.1007/s11695-010-0283-z.Peer-Reviewed Original ResearchConceptsGastric bypass patientsBody mass indexPhysical activityBypass patientsWeight lossBetter weight loss outcomesPreoperative body mass indexPsychosocial outcomesPhysical activity episodesGastric bypass surgeryPostoperative weight lossWeight loss outcomesBetter psychosocial outcomesBypass surgeryObese patientsMass indexPostoperative assessmentLoss outcomesBackgroundThis studySelf-reported frequencyPatientsPsychosocial functioningMental healthRegression analysisOutcomes
2009
Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study.
White MA, Kalarchian MA, Masheb RM, Marcus MD, Grilo CM. Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study. The Journal Of Clinical Psychiatry 2009, 71: 175-84. PMID: 19852902, PMCID: PMC2831110, DOI: 10.4088/jcp.08m04328blu.Peer-Reviewed Original ResearchConceptsBariatric surgery patientsSurgery patientsQuality of lifeGastric bypass surgery patientsDisorder psychopathologyWeight lossPostsurgical weight lossBypass surgery patientsWeight loss outcomesNegative prognostic indicatorBariatric surgeryPostoperative outcomesPostsurgical outcomesPrognostic indicatorBattery of assessmentsClinical significancePostsurgical improvementLoss outcomesMixed model analysisClinical attentionPatientsSurgeryPostsurgeryDepression levelsPsychosocial outcomes
2007
Do Patients’ Unrealistic Weight Goals Have Prognostic Significance for Bariatric Surgery?
White MA, Masheb RM, Rothschild BS, Burke-Martindale CH, Grilo CM. Do Patients’ Unrealistic Weight Goals Have Prognostic Significance for Bariatric Surgery? Obesity Surgery 2007, 17: 74-81. PMID: 17355772, DOI: 10.1007/s11695-007-9009-2.Peer-Reviewed Original ResearchConceptsUnrealistic weight goalsWeight loss goalsPrognostic significanceGoal weightBaseline BMISurgery patientsSurgical outcomesWeight lossWeight goalsUnrealistic weight loss goalsGastric bypass surgery candidatesBariatric surgery patientsNegative prognostic significanceWeight loss expectationsDisappointed weightGBP surgeryBariatric surgeryConsecutive seriesObese individualsStandard treatmentSurgery candidatesAcceptable BMISurgeryBMIPsychological functioning