2024
Takotsubo cardiomyopathy and cardiogenic shock due to hypokalaemic rhabdomyolysis
Hwang E, Namburar S, Siegel M, Sanchez A. Takotsubo cardiomyopathy and cardiogenic shock due to hypokalaemic rhabdomyolysis. BMJ Case Reports 2024, 17: e261456. PMID: 39419603, DOI: 10.1136/bcr-2024-261456.Peer-Reviewed Original ResearchConceptsTakotsubo cardiomyopathyCardiogenic shockAssociated with Takotsubo cardiomyopathyConsistent with cardiogenic shockConsistent with takotsubo cardiomyopathyTriggers of takotsubo cardiomyopathyCentral venous oxygen saturationInfluence cardiac morbidityChronic idiopathic constipationLow central venous oxygen saturationST-segment elevationVenous oxygen saturationWorsening cardiomyopathyGlobal hypokinesisPrognostic significanceCardiac morbidityIdiopathic constipationSpiked helmet signSegment elevationECG patternOxygen saturationCardiomyopathyRhabdomyolysisEchocardiographyEating disorders
2022
Imaging in the Intensive Care Unit
Toy D, Siegel M, Rubinowitz A. Imaging in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2022, 43: 899-923. PMID: 36442475, DOI: 10.1055/s-0042-1750041.Peer-Reviewed Original ResearchConceptsICU patientsIll patientsPathologic disease statesInterstitial lung diseaseIntensive care unitCT pulmonary angiographySpecific clinical scenariosModality of choicePortable chest radiographsHospital courseRadiologic manifestationsCare unitPleural effusionPulmonary angiographyLung diseaseICU settingChest radiographsSmall pneumothoracesRadiographic examinationAdditional abnormalitiesPatientsClinical scenariosPatient careInvasive devicesDiagnostic accuracy
2021
Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic. The Journal Of Clinical Ethics 2021, 32: 358-360. PMID: 34928864, DOI: 10.1086/jce2021324358.Commentaries, Editorials and LettersConceptsSOFA scoreBlack patientsCrisis standardsSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreAccurate prognostic scoresNext public health emergencyCOVID-19 patientsLife-saving medical resourcesMedical resourcesCOVID-19 pandemicSame scoring systemPublic health emergencyPrognostic scoreBody of evidenceRare casePatientsScoring systemTriage purposesAssessment scoresHealth emergencyCareHealthcare systemCOVID-19ScoresThe Other Side of Triage: When Access to Intensive Care Measures May Do More Harm than Good
Feder KJ, Zaidi D, Siegel MD. The Other Side of Triage: When Access to Intensive Care Measures May Do More Harm than Good. The American Journal Of Bioethics 2021, 21: 79-82. PMID: 34710018, DOI: 10.1080/15265161.2021.1980136.Peer-Reviewed Original ResearchChallenges in interpreting cytokine data in COVID-19 affect patient care and management
Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLOS Biology 2021, 19: e3001373. PMID: 34358229, PMCID: PMC8372945, DOI: 10.1371/journal.pbio.3001373.Peer-Reviewed Original Research
2020
Developing a Triage Protocol for the COVID-19 Pandemic: Allocating Scarce Medical Resources in a Public Health Emergency.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Developing a Triage Protocol for the COVID-19 Pandemic: Allocating Scarce Medical Resources in a Public Health Emergency. The Journal Of Clinical Ethics 2020, 31: 303-317. PMID: 32991327, DOI: 10.1086/jce2020314303.Peer-Reviewed Original ResearchConceptsPublic health emergencyTriage protocolScarce medical resourcesYale New Haven Health SystemMedical resourcesEthical challengesHealth emergencyCOVID-19 pandemicAllocating Scarce Medical ResourcesFuture wavesMajor ethical challengesChronic comorbiditiesPregnant patientsSimilar public health emergenciesHealthcare workersTriage assessmentClinical judgmentCoronavirus diseaseHealth systemSocioeconomic disparitiesRole of ageCOVID-19Less needPublic discussionSecondary goalMaking Medical Treatment Decisions for Unrepresented Patients in the ICU. An Official American Thoracic Society/American Geriatrics Society Policy Statement
Pope TM, Bennett J, Carson SS, Cederquist L, Cohen AB, DeMartino ES, Godfrey DM, Goodman-Crews P, Kapp MB, Lo B, Magnus DC, Reinke LF, Shirley JL, Siegel MD, Stapleton RD, Sudore RL, Tarzian AJ, Thornton JD, Wicclair MR, Widera EW, White DB. Making Medical Treatment Decisions for Unrepresented Patients in the ICU. An Official American Thoracic Society/American Geriatrics Society Policy Statement. American Journal Of Respiratory And Critical Care Medicine 2020, 201: 1182-1192. PMID: 32412853, PMCID: PMC7233335, DOI: 10.1164/rccm.202003-0512st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnrepresented patientsFair processProcedural due processMedical treatment decisionsPolicy statementsElder lawDue processHealth lawProcedural safeguardsState lawsUndue influenceLawCritical care settingAppropriate balanceAdvance directivesEthical goalsTreatment decisionsAppropriate medical careDiligent searchCapacity assessmentPatient advocacyInstitutionsPolicy recommendationsLess oversightCare settings
2019
A novel approach to the program evaluation committee
Schwartz AR, Siegel MD, Lee AI. A novel approach to the program evaluation committee. BMC Medical Education 2019, 19: 465. PMID: 31842868, PMCID: PMC6916454, DOI: 10.1186/s12909-019-1899-x.Peer-Reviewed Original ResearchConceptsProgram Evaluation CommitteePatient care experiencesResidency programsInternal medicine residency programsNon-medical servicesMedicine residency programsInterdisciplinary carePecs groupActionable feedbackCare experiencesAmbulatory rotationEvaluation CommitteeGraduate Medical EducationInpatientsForm of feedbackOutpatient rotationsAccreditation CouncilStructured group discussionsProgrammatic feedbackEducational curriculumQuality improvementMedical educationFaculty membersFacilitation skillsSurvey assessmentAntibiotics and the Yield of Blood Cultures: Sequence Matters.
Geer JH, Siegel MD. Antibiotics and the Yield of Blood Cultures: Sequence Matters. Annals Of Internal Medicine 2019, 171: 587-588. PMID: 31525773, DOI: 10.7326/m19-2489.Peer-Reviewed Original ResearchThe Unintended Consequences of Hope.
Siegel MD. The Unintended Consequences of Hope. Critical Care Medicine 2019, 47: 1267-1268. PMID: 31415310, DOI: 10.1097/CCM.0000000000003878.Peer-Reviewed Original ResearchEvaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours?
Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours? Annals Of Otology Rhinology & Laryngology 2019, 128: 619-624. PMID: 30841709, DOI: 10.1177/0003489419836115.Peer-Reviewed Original ResearchConceptsIntensive care unitSwallow evaluationDifferent intensive care unitsRe-intubation rateYale Swallow ProtocolMajority of patientsPost-extubation dysphagiaIntubation durationNosocomial pneumoniaPost extubationLonger hospitalizationCare unitProspective InvestigationSwallow ProtocolSwallowingHoursDysphagiaHospitalizationIntubationPneumoniaPatientsIncidenceEvaluation
2018
Internal medicine trainees' knowledge and confidence in using the American Society of Hematology Choosing Wisely guidelines in hemostasis, thrombosis, and non-malignant hematology
Marshall AL, Jenkins S, Oxentenko AS, Lee AI, Siegel MD, Katz JT, Vyas JM, Del Valle J, Mikhael JR. Internal medicine trainees' knowledge and confidence in using the American Society of Hematology Choosing Wisely guidelines in hemostasis, thrombosis, and non-malignant hematology. PLOS ONE 2018, 13: e0197414. PMID: 29768480, PMCID: PMC5955511, DOI: 10.1371/journal.pone.0197414.Peer-Reviewed Original ResearchA Young Man With Hemoptysis and Cavitary Lung Lesions
Brady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.Peer-Reviewed Case Reports and Technical NotesConceptsBacillus Calmette-Guérin (BCG) vaccineCavitary lung lesionsPrior cigarette smokingCalmette-Guérin vaccineHistory of alcoholIntermittent hemoptysisNight sweatsCigarette smokingMusculoskeletal symptomsLung lesionsMild fatigueDrug useWeight lossHemoptysisYoung menMenDyspneaRashMedicationsSmokingFeverVaccineLesionsSymptomsMonths
2017
A Sudden Loss Of Vision.
Siegel MD. A Sudden Loss Of Vision. Journal Of The American Geriatrics Society 2017, 65: 1882. PMID: 28555719, DOI: 10.1111/jgs.14946.Peer-Reviewed Original ResearchNot “Out of Sight, Out of Mind”
Bournival N, Siegel MD, Akgün KM. Not “Out of Sight, Out of Mind”. Critical Care Medicine 2017, 45: 134-136. PMID: 27984282, DOI: 10.1097/ccm.0000000000002119.Peer-Reviewed Original Research
2016
Immune-related sarcoidosis observed in combination ipilimumab and nivolumab therapy
Suozzi KC, Stahl M, Ko CJ, Chiang A, Gettinger SN, Siegel MD, Bunick CG. Immune-related sarcoidosis observed in combination ipilimumab and nivolumab therapy. JAAD Case Reports 2016, 2: 264-268. PMID: 27486590, PMCID: PMC4949498, DOI: 10.1016/j.jdcr.2016.05.002.Peer-Reviewed Original Research
2015
Critical Care at the End of Life
Akgün KM, Kapo JM, Siegel MD. Critical Care at the End of Life. Seminars In Respiratory And Critical Care Medicine 2015, 36: 921-933. PMID: 26600274, DOI: 10.1055/s-0035-1565254.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPalliative care skillsPalliative care modelCare modelCare skillsBasic palliative care skillsComplex palliative care needsIntensive care unit admissionCare unit admissionPalliative care consultationPalliative care needsPalliative care domainsChronic life-limiting conditionsFamily-centered endLife-limiting conditionsPeer support groupsUnit admissionEnd of lifeICU patientsSymptom managementCare consultationsICU providersCritical careIndividual ICUsICUCare needsUse of the Blom Tracheotomy Tube with Suction Inner Cannula to Decontaminate Microorganisms from the Subglottic Space. A Proof of Concept
Rabach L, Siegel MD, Puchalski JT, Towle D, Follert M, Johnson KM, Rademaker AW, Leder SB. Use of the Blom Tracheotomy Tube with Suction Inner Cannula to Decontaminate Microorganisms from the Subglottic Space. A Proof of Concept. Annals Of The American Thoracic Society 2015, 12: 859-863. PMID: 25849332, DOI: 10.1513/annalsats.201501-010bc.Peer-Reviewed Original ResearchConceptsMechanical ventilationTracheotomy tubeSubglottic spaceInner cannulaNormal floraPulmonary complicationsSignificant reductionOngoing mechanical ventilationEndotracheal tube intubationSingle-center studyTube intubationIll patientsEndotracheal tubeICU adultsSputum samplesTracheotomyMicrobiologic analysisCannulaVentilationComplicationsWeeksPathogensDurationSupraTracheostomyBringing Specialties Together: The Power of Intra-Professional Teams
Bongiovanni T, Long T, Khan AM, Siegel MD. Bringing Specialties Together: The Power of Intra-Professional Teams. Journal Of Graduate Medical Education 2015, 7: 19-20. PMID: 26217416, PMCID: PMC4507920, DOI: 10.4300/jgme-d-14-00509.1.Peer-Reviewed Original ResearchGuiding the guiders. Recognizing surrogates' needs and advancing communication in the intensive care unit.
Netzer G, Siegel MD. Guiding the guiders. Recognizing surrogates' needs and advancing communication in the intensive care unit. Annals Of The American Thoracic Society 2015, 12: 237-8. PMID: 25706488, DOI: 10.1513/AnnalsATS.201501-028ED.Peer-Reviewed Original Research