Modifying the Backbone Chemistry of PEG‐Based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles
Grundler J, Whang C, Shin K, Savan N, Zhong M, Saltzman W. Modifying the Backbone Chemistry of PEG‐Based Bottlebrush Block Copolymers for the Formation of Long‐Circulating Nanoparticles. Advanced Healthcare Materials 2024, 13: e2304040. PMID: 38734871, PMCID: PMC11368614, DOI: 10.1002/adhm.202304040.Peer-Reviewed Original ResearchBottlebrush block copolymersPerformance of nanoparticlesBottlebrush polymersBlock copolymersBiomedical applicationsLinear hydrophilic polymersBackbone chemistryLocation of functional groupsPoly(lactic acidBottlebrush backboneNanoparticle shellHydrophilic polymersPolymer backboneSurface functionalizationHeterobifunctional poly(ethylene glycolPoly(ethylene glycolHierarchical controlBlood circulation half-livesEnhanced tumor accumulationNanoparticlesPolymerReduced cellular uptakeNanoparticle physicochemical propertiesBottlebrushConventional nanoparticles