Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake
Grundler J, Shin K, Suh H, Whang C, Fulgoni G, Pierce R, Saltzman W. Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake. ACS Nano 2024, 18: 2815-2827. PMID: 38227820, DOI: 10.1021/acsnano.3c05921.Peer-Reviewed Original ResearchConceptsBottlebrush block copolymersSurface topographyBlock copolymersPoly(ethylene glycolClinical translation of nanomedicinePEGylated nanoparticlesEnhanced tumor uptakeNanoscale surface topographyTranslation of nanomedicinesRough surface topographyLinear block copolymersProlonged systemic circulationPerformance of nanocarriersPolymer coatingNanoparticle coatingSmooth surfaced nanoparticlesTumor uptakeTumor accumulationBiomedical applicationsNanoparticle formulationSystemic circulationClinical translationTumor extravasationNanoparticlesCoating