1999
An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin
Zhou D, Mooseker M, Galán J. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10176-10181. PMID: 10468582, PMCID: PMC17862, DOI: 10.1073/pnas.96.18.10176.Peer-Reviewed Original ResearchConceptsActin-bundling activityT-plastinBacterial-host cell contactHost cell signal transduction pathwaysHost cellsType III secretion systemBacterial effector proteinsActin-binding proteinsSignal transduction pathwaysBacterial effectorsMembrane rufflesEffector proteinsActin cytoskeletonMembrane rufflingSecretion systemSalmonella proteinsBacterial entryBacterial internalizationSalmonella entrySignaling processesActin filamentsF-actinNonphagocytic cellsProteinCell contactRole of the S. typhimurium Actin-Binding Protein SipA in Bacterial Internalization
Zhou D, Mooseker M, Galán J. Role of the S. typhimurium Actin-Binding Protein SipA in Bacterial Internalization. Science 1999, 283: 2092-2095. PMID: 10092234, DOI: 10.1126/science.283.5410.2092.Peer-Reviewed Original Research
1996
The actin-related proteins
Frankel S, Mooseker M. The actin-related proteins. Current Opinion In Cell Biology 1996, 8: 30-37. PMID: 8791406, DOI: 10.1016/s0955-0674(96)80045-7.Peer-Reviewed Original ResearchConceptsActin-related proteinsHsp/Hsc70Family of proteinsClear sequence homologyPrimary structural dataCell cycle proteinsStructural dataFunctional diversitySugar kinasesSequence homologyActin filamentsCycle proteinsFunctional contextProteinActinBiochemical analysisChromatinHsc70FamilyHomologyKinaseStructural elementsMicrotubulesMembersDiversity
1995
Molecular motors, membrane movements and physiology: emerging roles for myosins
Hasson T, Mooseker M. Molecular motors, membrane movements and physiology: emerging roles for myosins. Current Opinion In Cell Biology 1995, 7: 587-594. PMID: 7495580, DOI: 10.1016/0955-0674(95)80017-4.Peer-Reviewed Original ResearchConceptsMembrane protein functionMolecular motorsProtein functionSignal transductionNovel myosinOrganelle transportATP hydrolysisActin filamentsCell locomotionLarge familyMembrane movementUbiquitous associationMechanical forcesActinMyosinMembrane phenomenaTransductionMechanoenzymesMechanoregulationPhysiologyRolePhagocytosisMembraneFilamentsFamily
1993
Cloning of a Secretory Gelsolin from Drosophila melanogaster
Heintzelman M, Frankel S, Artavanis-Tsakonas S, Mooseker M. Cloning of a Secretory Gelsolin from Drosophila melanogaster. Journal Of Molecular Biology 1993, 230: 709-716. PMID: 8386771, DOI: 10.1006/jmbi.1993.1191.Peer-Reviewed Original ResearchConceptsSecretory gelsolinAcid sequenceThird instar Drosophila larvaeDeduced amino acid sequenceFull-length complementary DNAInstar Drosophila larvaeClass of proteinsActin-binding proteinsAmino acid sequenceAmino acid residuesGelsolin sequenceThird chromosomeDrosophila melanogasterGelsolin familyCytoplasmic proteinsSignal peptideSingle geneDrosophila larvaeRepeat structureActin filamentsMonomeric actinAcid residuesBarbed endsPrimary structureNorthern blot
1992
Localization of capping protein in chicken epithelial cells by immunofluorescence and biochemical fractionation.
Schafer D, Mooseker M, Cooper J. Localization of capping protein in chicken epithelial cells by immunofluorescence and biochemical fractionation. Journal Of Cell Biology 1992, 118: 335-346. PMID: 1629237, PMCID: PMC2290044, DOI: 10.1083/jcb.118.2.335.Peer-Reviewed Original ResearchMeSH KeywordsActin Depolymerizing FactorsActinsAnimalsAntibodiesCells, CulturedChick EmbryoChickensCochleaDestrinElectrophoresis, Polyacrylamide GelEpithelial CellsEpitheliumFluorescent Antibody TechniqueIntestinesKidneyMacromolecular SubstancesMicrofilament ProteinsMicrovilliMusclesPigment Epithelium of EyeSubcellular FractionsConceptsIntestinal epithelial cellsNuclei of cellsBiochemical fractionationJunctional complexesActin filamentsCell-cell junctional complexesSingle intestinal epithelial cellsBarbed endsEpithelial cellsSensory epitheliumCell-cell contactIntact intestinal epithelial cellsAffinity-purified polyclonal antibodiesProtein bindsCapping proteinIntestinal epitheliumZonula adherensCell junctionsChick embryo kidney cellsPattern coincidentEmbryo kidney cellsProteinConfocal microscopyKidney cellsIsolated intestinal epithelial cellsThe molecular architecture of an insect midgut brush border cytoskeleton.
Bonfanti P, Colombo A, Heintzelman M, Mooseker M, Camatini M. The molecular architecture of an insect midgut brush border cytoskeleton. European Journal Of Cell Biology 1992, 57: 298-307. PMID: 1511705.Peer-Reviewed Original ResearchConceptsTwo-dimensional gel analysisMolecular architectureMultiple isoelectric variantsBrush border cytoskeletonLepidopteran larvaeBB myosin IVertebrate intestineBrush borderMyosin IOrganelle exclusionHeavy meromyosin decorationCytoskeletal apparatusMyosin IINonmuscle cellsActin filamentsCytoskeletonIsoelectric variantsGel analysisInstar larvaeMajor isoformsStructural organizationRhodamine phalloidinCore proteinIntestinal brush borderMidgut
1991
Chapter 3 Structural and Functional Dissection of a Membrane-Bound Mechanoenzyme: Brush Border Myosin I
Mooseker M, Wolenski J, Coleman T, Hayden S, Cheney R, Espreafico E, Heintzelman M, Peterson M. Chapter 3 Structural and Functional Dissection of a Membrane-Bound Mechanoenzyme: Brush Border Myosin I. Current Topics In Membranes 1991, 38: 31-55. DOI: 10.1016/s0070-2161(08)60780-7.Peer-Reviewed Original ResearchBrush border myosin IBB myosin IMyosin ICalmodulin light chainsMicrovillar membraneProtein domain structureHeavy chainFunctional dissectionLight chainLinker proteinActin bindingMyosin I.Intestinal epithelial cellsActin filamentsMV membranePrimary structureApical membraneAcidic phospholipidsSubunit compositionTerminal webGlycoprotein bindsEpithelial cells
1988
A domain of synapsin I involved with actin bundling shares immunologic cross‐reactivity with villin
Petrucci T, Mooseker M, Morrow J. A domain of synapsin I involved with actin bundling shares immunologic cross‐reactivity with villin. Journal Of Cellular Biochemistry 1988, 36: 25-35. PMID: 3125185, DOI: 10.1002/jcb.240360104.Peer-Reviewed Original ResearchConceptsBovine synapsin ISynapsin IActin binding proteinsPeptide mappingTwo-dimensional peptide mapsSmall synaptic vesiclesPhosphorylation controlBundling proteinActin bindingUnrelated proteinsActin bundlesActin filamentsNeuronal phosphoproteinSynapsin I.Binding proteinVivo roleSynaptic vesiclesParent proteinProteinPeptide mapsChymotryptic digestionVillinPeptide fragmentsCross reactFragments
1986
Calcium and the Regulation of Cytoskeletal Assembly, Structure and Contractility
Mooseker M, Coleman T, Conzelman K. Calcium and the Regulation of Cytoskeletal Assembly, Structure and Contractility. Novartis Foundation Symposia 1986, 122: 232-249. PMID: 3792141, DOI: 10.1002/9780470513347.ch14.Peer-Reviewed Original ResearchConceptsActin-binding proteinsCytoskeletal assemblyActin filament interactionsCase of actinSubset of proteinsInteraction of actinActin assemblyCytoskeletal networkCytoskeletal structuresMode of Ca2Dependent regulationActin filamentsSpecific functionsProteinRegulationCentral roleActinFilament interactionAssemblyMyosin interactionCa2Functional classInteractionMembrane
1982
The Mechanism of Actin-Filament Assembly and Cross-Linking
Pollard T, Aebi U, Cooper J, Elzinga M, Fowler W, Griffith L, Herman I, Heuser J, Isenberg G, Kiehart D, Levy J, MacLean-Fletcher S, Maupin P, Mooseker M, Runge M, Smith P, Tseng P. The Mechanism of Actin-Filament Assembly and Cross-Linking. 1982, 15-44. DOI: 10.1007/978-1-4684-4037-9_2.Peer-Reviewed Original ResearchActin filamentsActin filament assemblyLocal contractile forcesRole of actinCertain enzyme systemsEukaryotic cellsFilaments of actinCellular motilityStructural proteinsCyto-skeletonMajor proteinsCell surfaceMost cellsMajor structural elementsProteinEnzyme systemActinContractile proteinsCytoplasmContractile apparatusFilamentsCellsInternal scaffoldingOrganellesStructural elements