2023
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus
Yang M, Lam T, Kanyo J, Kang I, Zhou Z, Clarke S, Mamula M. Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus. Autoimmunity 2023, 56: 2282945. PMID: 37994408, PMCID: PMC10897934, DOI: 10.1080/08916934.2023.2282945.Peer-Reviewed Original ResearchAutoimmunityHumansOxidative StressProtein D-Aspartate-L-Isoaspartate MethyltransferaseProtein Processing, Post-TranslationalT-LymphocytesZAP-70 Protein-Tyrosine Kinase
2001
Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme*
Young A, Carter W, Doyle H, Mamula M, Aswad D. Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme*. Journal Of Biological Chemistry 2001, 276: 37161-37165. PMID: 11479322, DOI: 10.1074/jbc.m106682200.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsCell NucleusHistonesIsoaspartic AcidMicePC12 CellsProtein ConformationProtein D-Aspartate-L-Isoaspartate MethyltransferaseRatsSubstrate SpecificityConceptsHistone H2BIsoaspartate (D-aspartate) O-methyltransferaseNormal gene regulationProtein repair enzymePIMT knockout miceActivity of proteinsRat PC12 cellsGene regulationProtein functionHistone H2B.Core histonesNuclear proteinsSubcellular fractionationProtein agingRepair enzymesH2BO-methyltransferaseAdenosine dialdehydeMethyltransferase inhibitorProtein LHistonesAsp-XaaPC12 cellsIsoAspStoichiometric levels