2013
Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152)
Yang M, Connolly S, Wen L, Herold K, Mamula M. Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152). The Journal Of Immunology 2013, 190: 172.3-172.3. DOI: 10.4049/jimmunol.190.supp.172.3.Peer-Reviewed Original ResearchNOD miceType 1 diabetesDiabetes-prone NOD miceEarly-onset diabetic patientsPre-diabetic NOD miceDiabetic NOD miceT cell autoimmunityPathogenesis of T1DPancreatic islet proteinsCell autoimmunityDiabetic patientsImmune toleranceRheumatoid arthritisMultiple sclerosisAutoimmune diseasesMurine modelTarget organsTherapeutic targetSelf proteinsPancreatic isletsIslet proteinsMiceOxidative stressPeripheral erythrocytesDiabetes
2008
Scavenger receptor type AI mediates antigen transfer from human B cells to other APCs
Harvey B, Quan T, Roman R, Rudenga B, Craft J, Mamula M. Scavenger receptor type AI mediates antigen transfer from human B cells to other APCs. The FASEB Journal 2008, 22: 1068.14-1068.14. DOI: 10.1096/fasebj.22.1_supplement.1068.14.Peer-Reviewed Original ResearchAntigen-presenting cellsProfessional antigen-presenting cellsB cellsAntigen transferTreatment of lupusInduction of autoimmunityTransfer of antigenUptake of antigensSpecific B cell receptorsNovel therapeutic targetMonocytic cell line THP-1Ig transgenic miceHuman monocytic cell line THP-1Cell line THP-1Human B cellsB cell receptorDendritic cellsChronic autoimmunityArthritis FoundationImmune responseAntigen traffickingB cell deathCritical antigensTherapeutic targetSpecific antigen