Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects.
Wang Y, Lian L, Flick M, Degen J, Lemmon M, Abrams C. Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects. Blood 2007, 110: 134. DOI: 10.1182/blood.v110.11.134.134.Peer-Reviewed Original ResearchPleckstrin-2PI3KSecond messengerSecretion defectNull plateletsPlatelet secretionPleckstrin homology domainTotal cellular proteinPI3K-dependent pathwayWild-type plateletsSpecific PI3KHomology domainCellular proteinsProtein phosphorylationPI3K inhibitorsPleckstrinFunction mutationsCritical effectorPKC inhibitorCompensatory pathwaysPKCPKC stimulantAlpha granulesK inhibitorsThrombin-induced secretion