2023
Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE
Chongsaritsinsuk J, Steigmeyer A, Mahoney K, Rosenfeld M, Lucas T, Smith C, Li A, Ince D, Kearns F, Battison A, Hollenhorst M, Judy Shon D, Tiemeyer K, Attah V, Kwon C, Bertozzi C, Ferracane M, Lemmon M, Amaro R, Malaker S. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. Nature Communications 2023, 14: 6169. PMID: 37794035, PMCID: PMC10550946, DOI: 10.1038/s41467-023-41756-y.Peer-Reviewed Original ResearchConceptsFamily of proteinsMucin domainO-glycosylationBiological functionsKey regulatorComplex glycansMass spectrometric analysisFunctional relevanceTIM familyDetailed molecular structureCritical roleGlycosylationProteinSpectrometric analysisStructural featuresUnique abilityStructural dynamicsMolecular dynamics simulationsTim-3 functionFamilyPowerful workflowRegulatorImmune cellsCheckpointGlycans
1993
Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain
Treutlein H, Lemmon M, Engleman D, Brunger A. Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain. 1993, i: 708-714 vol.1. DOI: 10.1109/hicss.1993.270670.Peer-Reviewed Original ResearchDimeric membrane proteinAmino acid sequenceRight-handed supercoilTransmembrane domainTransmembrane structureMembrane proteinsTransmembrane regionHelical proteinsMutagenesis dataHelix associationSecondary structureGlycophorin ALipid bilayersHelical dimerProteinStructural informationHelixConformationLocal energy minimaMembraneMolecular dynamics simulationsSupercoilsMutagenesisEnergy minimaInteraction energy