2007
Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects.
Wang Y, Lian L, Flick M, Degen J, Lemmon M, Abrams C. Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects. Blood 2007, 110: 134. DOI: 10.1182/blood.v110.11.134.134.Peer-Reviewed Original ResearchPleckstrin-2PI3KSecond messengerSecretion defectNull plateletsPlatelet secretionPleckstrin homology domainTotal cellular proteinPI3K-dependent pathwayWild-type plateletsSpecific PI3KHomology domainCellular proteinsProtein phosphorylationPI3K inhibitorsPleckstrinFunction mutationsCritical effectorPKC inhibitorCompensatory pathwaysPKCPKC stimulantAlpha granulesK inhibitorsThrombin-induced secretion
2006
Knockout of the PKC Substrate Pleckstrin Causes Pleomorphic Defects in Platelets, Lymphocytes and Granulocytes.
Lian L, Wang Y, Chen X, Bach T, Lenox L, Zhu P, Flick M, Scott E, Degen J, Freedman B, Koretzky G, Lemmon M, Abrams C. Knockout of the PKC Substrate Pleckstrin Causes Pleomorphic Defects in Platelets, Lymphocytes and Granulocytes. Blood 2006, 108: 394. DOI: 10.1182/blood.v108.11.394.394.Peer-Reviewed Original ResearchSecond messengerPI3KPI3K inhibitorsCarboxyl-terminal pleckstrin homology domainPleckstrin homology domainPhospholipid second messengerWild-type cellsTotal cellular proteinMultiple hematopoietic lineagesK inhibitorsMendelian inheritance patternWild-type plateletsPhosphorylated pleckstrinHomology domainCytoskeletal dynamicsRole of PKCDEP domainExocytosis defectsCellular proteinsCytoskeletal defectsCytoskeletal reorganizationMembrane extensionsReactive oxygen speciesHematopoietic lineagesPleckstrin