2009
Regulation of the epidermal growth factor receptor intracellular domain
Choi S, Lemmon M. Regulation of the epidermal growth factor receptor intracellular domain. The FASEB Journal 2009, 23: 883.2-883.2. DOI: 10.1096/fasebj.23.1_supplement.883.2.Peer-Reviewed Original ResearchC-terminal tailTyrosine kinase domainIntracellular domainJuxtamembrane regionJM regionEGFR intracellular domainEpidermal growth factor receptorC-tailEGFR extracellular regionC-tail regionReceptor intracellular domainEffects of mutationsReceptor tyrosine kinasesReceptor-receptor interactionsSmall-angle X-ray scatteringKinase assaysKinase domainGrowth factor receptorExtracellular regionReceptor dimerizationEGFR activationBaculovirus systemIntracellular dimerTyrosine kinaseDeletion mutations
2002
Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization
Yu J, Lemmon M. Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization. 2002 DOI: 10.21236/ada409630.Peer-Reviewed Original ResearchB cell linesErbB2 interactsBreast cancer therapyAbsence of IL2B cell proliferationIL2 receptor betaBreast cancerReceptor betaERBB2 overexpressionErbB receptor ligandsReceptor ligandsErbB2Cancer therapyValuable targetVivo systemGamma chainIntracellular domainMechanism of activationExtracellular domain