210 Regulation of TIM-3 by phosphatidylserine
Smith C, Li A, Krishnamurthy N, Lemmon M. 210 Regulation of TIM-3 by phosphatidylserine. Journal For ImmunoTherapy Of Cancer 2020, 8: a229-a229. DOI: 10.1136/jitc-2020-sitc2020.0210.Peer-Reviewed Original ResearchTim-3-expressing cellsTim-3 antibodyTim-3 functionTim-3Exhausted T cellsT cell signalingPD-1Receptor expressionT cellsTIM-1Tumor antigen-specific CD8Role of PST cell exhaustion phenotypeTim-3 receptorAntigen-specific CD8PD-1-mediated inhibitionPD-1 expressionImmune checkpoint blockadeMajority of patientsCheckpoint blockade therapyT cell dysfunctionImmune checkpoint receptorsAcute myelogenous leukemiaApoptotic cellsNew therapeutic targets