2017
Identification of differentially expressed genes associated with clinical response after treatment of breast cancer skin metastases with imiquimod.
Rozenblit M, Heguy A, Chiriboga L, Loomis C, Darvishian F, Egeblad M, Shao Y, Adams S. Identification of differentially expressed genes associated with clinical response after treatment of breast cancer skin metastases with imiquimod. Journal Of Clinical Oncology 2017, 35: e12541-e12541. DOI: 10.1200/jco.2017.35.15_suppl.e12541.Peer-Reviewed Original ResearchBreast cancer skin metastasesSkin metastasesClinical responseImiquimod treatmentInnate immunityNK cellsT cellsB cellsToll-like receptor 7 agonistAnti-tumor immune responseER/PR statusPanCancer Immune Profiling PanelUpregulation of genesReceptor 7 agonistNK cell functionImmune Profiling PanelPossible combination therapiesUpregulation of TNFGene expression changesActivation of lymphocytesExpression changesTop upregulated genesPrediction of responseIL-17Non responders
2014
Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response
Dhingra N, Shemer A, da Rosa J, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. Journal Of Allergy And Clinical Immunology 2014, 134: 362-372. PMID: 24768652, DOI: 10.1016/j.jaci.2014.03.009.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisHuman allergic contact dermatitisTh1/Th17Different allergensHigher immune activationMurine contact hypersensitivityStrong Th2 biasContact hypersensitivity modelCommon occupational diseaseT cell activationTh22 polarizationCommon allergensContact hypersensitivityTh2 biasDermatitis skinImmune activationClinical reactionsHypersensitivity modelImmune polarizationIndividual allergensContact dermatitisImmune responseAllergen groupsInnate immunityOccupational diseases