2019
Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod
Rozenblit M, Hendrickx W, Heguy A, Chiriboga L, Loomis C, Ray K, Darvishian F, Egeblad M, Demaria S, Marincola FM, Bedognetti D, Adams S. Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod. Scientific Reports 2019, 9: 8572. PMID: 31189943, PMCID: PMC6561945, DOI: 10.1038/s41598-019-42784-9.Peer-Reviewed Original ResearchConceptsBreast cancer skin metastasesBreast cancer metastasisSkin metastasesImmune responsePost-treatment tumor samplesCancer metastasisReceptor 7 agonistStrong T-helperDurable clinical responsesImmune effector functionsBasal cell carcinomaRobust immune responseTopical imiquimodClinical responseT helperTumor rejectionCell carcinomaCytotoxic functionTranscriptomic profilesTumor regressionClinical trialsAntigen presentationT cellsImiquimodTumor destruction
2014
Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response
Dhingra N, Shemer A, da Rosa J, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. Journal Of Allergy And Clinical Immunology 2014, 134: 362-372. PMID: 24768652, DOI: 10.1016/j.jaci.2014.03.009.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisHuman allergic contact dermatitisTh1/Th17Different allergensHigher immune activationMurine contact hypersensitivityStrong Th2 biasContact hypersensitivity modelCommon occupational diseaseT cell activationTh22 polarizationCommon allergensContact hypersensitivityTh2 biasDermatitis skinImmune activationClinical reactionsHypersensitivity modelImmune polarizationIndividual allergensContact dermatitisImmune responseAllergen groupsInnate immunityOccupational diseases