2015
Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin
da Rosa J, Malajian D, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Khattri S, Ungar B, Finney R, Xu H, Zheng X, Estrada YD, Peng X, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. Journal Of Allergy And Clinical Immunology 2015, 135: 712-720. PMID: 25583101, DOI: 10.1016/j.jaci.2014.11.017.Peer-Reviewed Original ResearchConceptsAtopic dermatitisAllergic contact dermatitis reactionsBackground Atopic dermatitisContact hypersensitivity responseTh17/ILCommon contact allergensNon-AD groupAllergic immune reactionsAllergic contact dermatitisCommon inflammatory diseaseTissue immune responseContact dermatitis reactionsTh1 productsTh2 productsAllergen challengeImmune abnormalitiesAllergic sensitizationCommon allergensTh1 subsetContact sensitizationHypersensitivity responseInflammatory productsBiopsy specimensInflammatory diseasesContact allergens
2014
Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology
Khattri S, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Finney R, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, de Guzman Strong C, Gonzalez J, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology. Journal Of Allergy And Clinical Immunology 2014, 133: 1626-1634. PMID: 24786238, PMCID: PMC4122665, DOI: 10.1016/j.jaci.2014.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiomarkersCluster AnalysisCyclosporineDendritic CellsDermatitis, AtopicEpidermisFemaleGene Expression ProfilingGene Expression RegulationHumansHyperplasiaImmunosuppressive AgentsInflammationMaleMiddle AgedPhenotypeSignal TransductionT-Lymphocyte SubsetsTreatment OutcomeYoung AdultConceptsClinical improvementAtopic dermatitisCytokine activationEpidermal alterationsAD skin lesionsEpidermal pathologyWeeks of treatmentT cell cytokinesCommon inflammatory diseaseSystemic immunosuppressantsSCORAD scoreNonlesional skinWeek 12Inflammatory pathwaysTissue inflammationBiopsy specimensInflammatory diseasesSignificant gene expression changesSevere diseaseEpidermal hyperplasiaImmunohistochemistry studiesSkin lesionsSpecific cytokinesWeek 2CsA effects