Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites
Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, MacInnis B, Kwiatkowski DP, Conway DJ. Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites. PLOS Genetics 2012, 8: e1002992. PMID: 23133397, PMCID: PMC3486833, DOI: 10.1371/journal.pgen.1002992.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsPaired-end short-read sequencesHistorical population expansionPopulation genomic scansHuman malaria parasite Plasmodium falciparumMinority of genesMalaria parasite Plasmodium falciparumSite frequency spectrumPhase-variable expressionShort read sequencesParasite Plasmodium falciparumBalancing selectionGene familyGenomic scansReference genomeClonal parasite linesPopulation expansionSequence dataProtein productsParasite linesGenesMerozoite stageFunctional studiesSchizont stageNucleotide polymorphisms