2011
Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma R. Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury. Journal Of Neurotrauma 2011, 28: 2417-2427. PMID: 21970496, PMCID: PMC3235339, DOI: 10.1089/neu.2011.1853.Peer-Reviewed Original ResearchConceptsSpinal cord injuryInflammatory responseSpinal cordSelective CB2 agonistAutonomic functionCord injuryMotor functionCB2 agonistsToll-like receptor expressionChemokine/cytokine expressionIL-23p19 expressionCell invasionInflammatory cell invasionSignificant reductionContusion injuryPercentage of animalsCXCL-9Immunoreactive microgliaCXCL-11Cytokine expressionIL-23RReceptor expressionInflammatory reactionInjuryEntire study periodNovel mechanisms of immune modulation of natalizumab in multiple sclerosis patients
Skarica M, Eckstein C, Whartenby K, Calabresi P. Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. Journal Of Neuroimmunology 2011, 235: 70-76. PMID: 21550672, DOI: 10.1016/j.jneuroim.2011.02.010.Peer-Reviewed Original ResearchConceptsNatalizumab therapyPeripheral bloodMonth timepointProportion of CD20Proportion of CD4Number of CD14Multiple sclerosis patientsImmune cell compositionHematopoetic stem cellsPercentage of cellsMechanism of actionNatalizumab treatmentRRMS patientsMS patientsNK cellsSclerosis patientsTreatment onsetCytokine productionImmune compositionImmune modulationImmune cellsT cellsB cellsPatientsTherapy
2010
Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs
Sabolić I, Breljak D, Škarica M, Herak-Kramberger C. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. BioMetals 2010, 23: 897-926. PMID: 20549307, DOI: 10.1007/s10534-010-9351-z.Peer-Reviewed Original ResearchConceptsProximal tubule cellsChronic toxicityTubular injuryRole of metallothioneinMT-1Intracellular MTSquamous epitheliumCytotoxicity of CdChronic intoxicationTubule cellsVariety of stimuliRole of MTKidneyMajor physiological functionsMT-2Oxidative stressAdult mammalsMT-4Acute toxicityMajor targetMT-3Essential metals ZnMost tissuesToxicityDe novo synthesis
2009
Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis
Skarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, Whartenby K. Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2009, 182: 4192-4199. PMID: 19299717, PMCID: PMC3727416, DOI: 10.4049/jimmunol.0803631.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisPeripheral dendritic cellsDendritic cellsT cellsSignal transduction inhibitorsAutoimmune encephalomyelitisMultiple sclerosisIFN-gamma-secreting T cellsBone marrow chimera systemAg-specific T cellsTransduction inhibitorsT cell responsesT cell subsetsSignal transduction inhibitionCNS infiltrationCytokine polarizationIL-17IL-23Th1 responseAutoimmune responseCell subsetsCostimulatory moleculesIL-6TNF-alphaCEP-701
2005
Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences
Sabolić I, Škarica M, Gorboulev V, Ljubojević M, Balen D, Herak-Kramberger C, Koepsell H. Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences. American Journal Of Physiology. Renal Physiology 2005, 290: f913-f926. PMID: 16204409, DOI: 10.1152/ajprenal.00270.2005.Peer-Reviewed Original ResearchConceptsBrush border membraneProximal tubulesPT segmentsRat SGLT1Gender differencesExpression of SGLT1Androgen inhibitionRenal capsuleSmooth musclePeptide-specific polyclonal antibodiesRat kidneyGlucose transporter SGLT1S3 segmentBlood vesselsPart of glucoseImmunoblotting dataMRNA levelsMammalian proximal tubuleMedullary raysBBM vesiclesTissue cryosectionsTransporter SGLT1KidneySGLT1Immunostaining