The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research
Steffens D, Fahed M, Manning K, Wang L. The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research. Translational Psychiatry 2022, 12: 525. PMID: 36572691, PMCID: PMC9792580, DOI: 10.1038/s41398-022-02292-3.Peer-Reviewed Original ResearchConceptsPrefrontal cortex circuitCortex circuitPeripheral biomarkersPresence of apathyNeurobiology of apathyPoor health outcomesDefinitive treatmentFuture studiesApathy symptomsClinical managementNeuropsychiatric comorbiditiesFunctional declineCommon conditionNeurocognitive impairmentCognitive disordersNeuropsychological featuresHealth outcomesCognitive impairmentBrain circuitryNeuropsychiatric disordersPrefrontal cortexOlder adultsClinical realityBiomarker researchImpairment