2021
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
Cheemarla NR, Watkins TA, Mihaylova VT, Wang B, Zhao D, Wang G, Landry ML, Foxman EF. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics. Journal Of Experimental Medicine 2021, 218: e20210583. PMID: 34128960, PMCID: PMC8210587, DOI: 10.1084/jem.20210583.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngiotensin-Converting Enzyme 2Case-Control StudiesChemokine CXCL10COVID-19Disease SusceptibilityFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansImmunity, InnateInterferonsMaleMiddle AgedNasopharynxPicornaviridae InfectionsSARS-CoV-2Viral LoadVirus ReplicationConceptsSARS-CoV-2 infectionSARS-CoV-2 exposureSARS-CoV-2Interferon-stimulated genesUpper respiratory tractRespiratory tractEarly SARS-CoV-2 infectionDynamic innate immune responseViral replicationSARS-CoV-2 replicationPatient nasopharyngeal samplesInnate immune responseLow infectious doseViral loadNasopharyngeal samplesImmune responseInfectious doseISG responseAntiviral responseInfection progressionViral transmissionLevel correlatesInfectionISG inductionInitial replication
2005
Association between a Novel Human Coronavirus and Kawasaki Disease
Esper F, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Association between a Novel Human Coronavirus and Kawasaki Disease. The Journal Of Infectious Diseases 2005, 191: 499-502. PMID: 15655771, PMCID: PMC7199489, DOI: 10.1086/428291.Peer-Reviewed Original ResearchConceptsKawasaki diseaseNovel human coronavirusRespiratory secretionsHuman coronavirusesClassic Kawasaki diseaseNew Haven coronavirusCase-control studyReverse transcriptase-polymerase chain reactionSystemic vasculitisControl subjectsPolymerase chain reactionPossible associationDiseaseChain reactionInfectionCoronavirusSecretionAssociationVasculitisInfantsEtiology